SOURCE: Protherics PLC

October 23, 2007 07:17 ET

Protherics PLC - Holding(s) in Company

Cheshire, UK--(Marketwire - October 23, 2007) -

                           Protherics PLC

             Notification of Major Interests in Shares

London, UK; Brentwood, TN, US: 23 October 2007 - Protherics PLC
("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, announces that on 19 October
2007, in accordance with the Transparency Obligations Directive, a
notification of interest in the ordinary share capital of the Company was
received from AXA Investment Managers UK Limited on behalf of AXA S.A.
and its Group Companies ("AXA").  Details of the interest notified are as
follows:

1. Reason for the notification (please tick the appropriate box or boxes)

An acquisition of voting rights                                   X

An acquisition or disposal of financial instruments which may result in
the acquisition of shares already issued to which voting rights are
attached

An event changing the breakdown of voting rights

Other (please specify):

2. Full name of person(s) subject to the  AXA S.A., 25 Avenue Matignon,
   notification obligation:               75008 Paris and its
                                          group of companies.

3. Full name of shareholder(s) (if different
   from 2.):

4. Date of the transaction (and date on which       18 October 2007
   the threshold is crossed or reached if
   different):

5. Date on which issuer notified:                   19 October 2007

6. Threshold(s) that is/are crossed or
   reached:                                         12%

7. Notified details:


A: Voting rights attached to shares

Class/type of     Situation previous to    Resulting situation after the
shares            the Triggering           triggering transaction
                  transaction

if possible using Number of   Number of   Number of       Number of
the ISIN CODE     Shares      of voting   shares        voting rights
                              Rights      Direct      Direct   Indirect
0702920           39,349,221  39,349,221  829,525     829,525  40,853,708

% of voting rights
Direct    Indirect
0.24%     12.04%



B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial    Exercise/ Conversion   Number of             % of
instrument           Period/ Date           voting rights         voting
                                            that may be acquired  rights
           Expiration                       if the instrument
             date                           is exercised/ 
                                            converted. 

Total (A+B)
Number of voting rights                           % of voting rights
 41,683,233                                              12.28%


8. Chain of controlled undertakings through which the voting rights
and/or the financial instruments are effectively held, if applicable :
 
Name of Company/Fund                    Number of Shares         % of  
                                                               issued 
                                                            share capital

AXA UK Investment Co ICVC                    520,429            0.15336
UK Smaller Companies Fund
                     Indirect

Sun Life Pensions Management Ltd              25,000            0.00737
                      Direct
AXA Sun Life                                  53,913            0.01589
FTSE All Share Tracker Life
                      Direct
AXA Sun Life                                 294,874            0.08689
FTSE All Share Tracker Pension
                      Direct
AXA Framlington                              750,000            0.22101
SEI UK Equity
                     Indirect
AXA Framlington                              854,587            0.25183
St James Place Exempt (Pens) Fund
                     Indirect
AXA Framlington                              961,409            0.28331
St James Place Net (Life) Fund
                     Indirect

AXA Framlington                              213,646            0.06296
St James Place Offshore Fund
                     Indirect
AXA Framlington                              320,470            0.09444
Daimler Chrysler
                     Indirect
AXA Framlington                            3,120,333            0.91951
Throgmorton Trust
                     Indirect
AXA Framlington                           15,013,453            4.42422
UK Selet Ops
                     Indirect
AXA Framlington                           13,753,131            4.05282
Equity Income
                     Indirect
AXA Framlington                            2,000,000            0.58937
Managed Balanced
                     Indirect
AXA Framlington                            1,500,000            0.44203
UK Smaller Companies
                     Indirect
AXA Framlington                              500,000            0.14734
BAE Systems Pensions Fund CIF Trustees
                     Indirect
AXA Framlington                              220,000            0.06483
BAE Systems 2000 Pensions Fund
                     Indirect

AXA Framlington onshore private clients      970,000            0.28584
                     Indirect

AXA Framlington onshire private clients       56,250            0.01658
                     Indirect
AXA Sun Life plc                             271,631            0.08005
With Profit Transition Fund
                      Direct

AXA Life Assurance Society plc               184,107            0.05425
With Profit Transition Fund
                      Direct
AXA Framlington                              100,000            0.02947
ST James Place Internal Equity & Income UT
                     Indirect


                         Total Direct        829,525            0.24445

                       Total Indirect     40,853,708           12.03892


                              TOTAL       41,683,233           12.28337

Proxy Voting:

9.  Name of the proxy holder:

10. Number of voting rights proxy holder will cease to hold:

11. Date on which proxy holder will cease to hold voting
    rights:

12. Additional information:



                                   |  Ends  |



For further information please contact:


Protherics
Nick Staples, Director of Corporate Affairs        +44 (0) 7919  480510
Julie Vickers, Company Secretary                   +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Lara Mott                      +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt             +1 212 850 5600


Or visit  www.protherics.com


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