SOURCE: Protherics PLC

December 21, 2007 12:36 ET

Protherics PLC - Notification of Major Interests in Shares

Cheshire, UK--(Marketwire - December 21, 2007) -

                                 Protherics PLC

                   Notification of Major Interests in Shares

London, UK; Brentwood, TN, US: 21 December 2007 - Protherics PLC ("Protherics"
or the "Company"), the international biopharmaceutical company focused on
critical care and cancer, announces that on 20 December 2007, in accordance with
the Transparency Obligations Directive, a notification of interest in the
ordinary share capital of the Company was received from AXA Investment Managers
UK Limited on behalf of AXA S.A. and its Group Companies ("AXA").  The
notification follows an increase in the Indirect holding of AXA.  Details of the
interest notified are as follows:

1. Reason for the notification (please tick the appropriate box or boxes)

An acquisition of voting rights                                              X
An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached

An event changing the breakdown of voting rights

Other (please specify):

2. Full name of person(s) subject to the           AXA S.A., 25 Avenue Matignon, 75008 Paris and its
   notification obligation:                                          group of companies.

3. Full name of shareholder(s) (if different
   from 2.):

4. Date of the transaction (and date on which                       18 December 2007
   the threshold is crossed or reached if

5. Date on which issuer notified:                                   19 December 2007

6. Threshold(s) that is/are crossed or reached:                           14%

7. Notified details:

A: Voting rights attached to shares
Class/type of     Situation previous to    Resulting situation after the triggering transaction
shares            the Triggering
if possible using Number of   Number of    Number of     Number of voting rights     % of voting rights
the ISIN CODE     Shares      Voting       shares
                              Rights       Direct        Direct        Indirect      Direct    Indirect
0702920           43,726,012  43,726,012   741,666       741,666       48,854,003    0.22%     14.36%

B: Financial Instruments
Resulting situation after the triggering transaction
Type of financial    Expiration date Exercise/ Conversion      Number of voting rights    % of voting rights
instrument                           Period/ Date              that may be acquired if
                                                               the instrument is
                                                               exercised/ converted.

Total (A+B)
Number of voting rights                           % of voting rights
49,595,669                                        14.58%

8. Chain of controlled undertakings through which the voting rights and/or the financial instruments are
effectively held, if applicable :

Name of Company/Fund              Number of Shares    % of issued share capital

AXA UK Investment Co ICVC               551,929               0.16224
UK Smaller Companies Fund
Sun Life Pensions Management Ltd         25,000               0.00735
Sun Life Unit Assurance Ltd              53,913               0.01585
FTSE All Share Tracker
Sun Life Pensions Management            294,874               0.08668
FTSE All Share Tracker
AXA Framlington                         750,000               0.22046
SEI UK Equity
AXA Framlington                       1,600,000               0.47031
St James Place Exempt (Pens) Fund
AXA Framlington                       1,800,000               0.52910
St James Place Net (Life) Fund
AXA Framlington                         400,000               0.11758
St James Place Offshore Fund
AXA Framlington                         600,000               0.17637
Daimler Chrysler
AXA Framlington                       3,120,333               0.91720
Throgmorton Trust
AXA Framlington                      15,013,453               4.41308
UK Select Ops
AXA Framlington                      13,753,131               4.04262
Equity Income
AXA Framlington                       2,000,000               0.58788
Managed Balanced
AXA Framlington                       1,500,000               0.44091
UK Smaller Companies
AXA Framlington                         500,000               0.14697
BAE Systems Pensions Fund CIF Trustees
AXA Framlington                         220,000               0.06467
BAE Systems 2000 Pensions Fund
Framlington onshore private clients   6,820,157               2.00473
Axa Sun Life With Profits Passive       226,817               0.06667
Sun Life Ass With Profits Passive       141,062               0.04146
AXA Framlington
St James Place Internal 
Equity & Income UT                      225,000               0.06614

                   Total Direct         741,666               0.21801
                 Total Indirect      48,854,003              14.36024
                          TOTAL      49,595,669              14.57825

Proxy Voting:

9.  Name of the proxy holder:
10. Number of voting rights proxy holder will cease to hold:
11. Date on which proxy holder will cease to hold voting

12. Additional information:

                                   |  Ends  |

For further information please contact:

Nick Staples, Director of Corporate Affairs         +44 (0) 7919  480510
Julie Vickers, Company Secretary                      +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Lara Mott                       +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt                  +1 212 850 5600

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