SOURCE: Protherics PLC

September 22, 2006 12:41 ET

Protherics PLC announces Holding(s) in Company

Cheshire, UK -- (MARKET WIRE) -- September 22, 2006 --

                                 Protherics PLC

                    Notification of Major Interest in Shares

22 September 2006 - Protherics PLC ("Protherics" or the "Company"), the international biopharmaceutical company focused on critical care and cancer, received notification from Fidelity International on 21 September 2006 that, as at 21 September 2006, FMR Corp. and its direct and indirect subsidiaries, and Fidelity International Limited and its direct and indirect subsidiaries, both being non-beneficial holders, together held an interest in 7,797,770 ordinary shares, representing 2.99% of the issued share capital of the Company.

This notification follows a reduction of 2,517,503 ordinary shares in their holding, representing 0.97% of the issued share capital of the Company.

The current issued share capital of the Company is 260,813,157 ordinary shares.

                                 |  Ends  |


For further information please contact:

Protherics
Nick Staples, Director of Corporate Affairs         +44 (0)7919 480510
Julie Vickers, Company Secretary                    +44 (0)1928 518010

Financial Dynamics - press enquiries
Ben Atwell, David Yates                             +44 (0)20 7831 3113





                      This information is provided by RNS
            The company news service from the London Stock Exchange