SOURCE: Smith & Nephew PLC

June 08, 2007 12:41 ET

Smith & Nephew PLC announce Holding(s) in Company

London, UK--(Marketwire - June 8, 2007) -

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES

1. Name of company

Smith & Nephew plc

2. Name of shareholder having a major interest

Capital Research and Management Company

3. Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above or in respect of a non-beneficial interest or in the case of an individual holder if it is a holding of that person's spouse or children under the age of 18

Non-beneficial

4. Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them

...............................................................

5. Number of shares / amount of stock acquired

...............................................................

6. Percentage of issued class

...............................................................

7. Number of shares / amount of stock disposed

8,949,999

8. Percentage of issued class

...............................................................

9. Class of security

Ordinary shares of US 20 cents

10. Date of transaction

07.06.2007

11. Date company informed

08.06.2007

12. Total holding following this notification

101,380,679

13. Total percentage holding of issued class following this notification

10.87%

14. Any additional information

The Capital Group Companies Inc no longer reports ownership of securities. Capital Research and Management Company and Capital Group International Inc, now report relevant holdings separately for the purposes of the DTR Handbook.

15. Name of contact and telephone number for queries

Phil Higgins - Assistant Company Secretary 020 7960 2228

16. Name and signature of authorised company official responsible for making this notification

Phil Higgins - Assistant Company Secretary

Date of notification

08.06.07

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