SOURCE: Smith & Nephew PLC

October 26, 2007 12:48 ET

Smith & Nephew PLC announces Holding(s) in Company

London, UK--(Marketwire - October 26, 2007) -

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES

1. Name of company

Smith & Nephew plc

2. Name of shareholder having a major interest

Newton Investment Management Limited

3. Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above or in respect of a non- beneficial interest or in the case of an individual holder if it is a holding of that person's spouse or children under the age of 18

Non-beneficial

4. Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them

...............................................................

5. Number of shares / amount of stock acquired

...................................................

6. Percentage of issued class

...............................................................

7. Number of shares / amount of stock disposed

3,199,350

8. Percentage of issued class

...............................................................

9. Class of security

Ordinary shares of US 20 cents

10. Date of transaction

25.10.07

11. Date company informed

26.10.07

12. Total holding following this notification

24,756,402

13. Total percentage holding of issued class following this notification

2.74%

14. Any additional information

This notification is further to the receipt of a TR1 Form in accordance with the Disclosure and Transparency Rules.

15. Name of contact and telephone number for queries

Phil Higgins - Assistant Company Secretary

020 7960 2228

16. Name and signature of authorised company official responsible for making this notification

Phil Higgins - Assistant Company Secretary

Date of notification

26.10.07

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