SOURCE: Smith & Nephew PLC

August 25, 2006 06:16 ET

Smith & Nephew plc announces Holding(s) in Company

London, UK -- (MARKET WIRE) -- August 25, 2006 --

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES

1. Name of company

Smith & Nephew plc

2. Name of shareholder having a major interest

The Capital Group Companies, Inc.

3. Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above or in respect of a non-beneficial interest or in the case of an individual holder if it is a holding of that person's spouse or children under the age of 18

Non-beneficial

4. Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them

Capital Guardian Trust Company:

State Street Nominees Ltd 2,286,200

Bank Of New York Nominees Ltd 1,373,118

Northern Trust 243,500

Chase Manhattan Bank Australia Ltd 3,100

Chase Nominees Ltd 9,286,566

BT Globenet Nominees Ltd 350,100

Midland Bank plc 1,473,600

Cede & Co 113,700

Deutsche Bank Mannheim 4,500

Bankers Trust 538,145

Barclays Bank 93,000

Brown Bros 42,700

Nortrust Nominees 3,691,034

MSS Nominees Ltd 64,700

State Street Bank & Trust Co 134,500

Citibank 9,800

Citibank NA 32,000

Deutsche Bank AG 3,600

HSBC Bank plc 2,900

Mellon Bank NA 132,000

ROY Nominees Ltd 23,900

Mellon Nominees (UK) Ltd 750,400

HSBC 33,800

JP Morgan Chase Bank 954,133

Capital International Ltd:

State Street Nominees Ltd 67,100

Bank of New York Nominees 1,190,517

Northern Trust 386,544

Chase Nominees Ltd 710,493

Midland Bank plc 125,600

Citibank London 13,500

Morgan Guaranty 77,500

Nortrust Nominees 762,972

MSS Nominees Limited 16,200

State Street Bank & Trust Co 362,100

Lloyds Bank 3,900

Citibank 8,300

Citibank NA 382,700

Deutsche Bank AG 24,700

HSBC Bank plc 291,265

Mellon Bank NA 28,700

Northern Trust AVFC 80,038

KAS UK 33,000

Mellon Nominees (UK) Ltd 48,600

Bank One London 48,400

JP Morgan Chase Bank 7,100

Raiffeisen Zentral Bank 348,300

Fortis Bank 10,500

Metzler Seel Sohn & Co. 8,100

Nordea Bank 75,900

Bayerische Hypo Und Vereinsbank AG 13,000

Capital International SA:

Chase Nominees Ltd 452,500

Midland Bank plc 11,000

Pictet & Cie 50,100

State Street Bank & Trust Co 39,000

Lloyds Bank 18,500

HSBC Bank plc 150,900

JP Morgan Chase Bank 12,900

Metzler Seel Sohn & Co. 11,600

Capital Research and Management Company:

State Street Nominees Ltd 23,381,800

Chase Nominees Ltd 109,191,771

JPM Nominees Ltd 30,000

State Street Bank & Trust Co 182,000

Capital International Inc

State Street Nominees Limited 647,800

Bank of New York Nominees 243,800

Northern Trust 15,400

Chase Nominees Limited 761,000

Midland Bank 19,000

Bankers Trust 11,200

Nortrust Nominees 136,300

State Street Bank & Trust Co 47,900

Citibank 9,000

Citibank NA 132,700

HSBC Bank plc 35,400

JP Morgan Chase Bank 38,100

5. Number of shares / amount of stock acquired

Not disclosed

6. Percentage of issued class

Not disclosed

7. Number of shares / amount of stock disposed

...............................................................

8. Percentage of issued class

...............................................................

9. Class of security

Ordinary shares of US 20 cents

10. Date of transaction

23.08.06

11. Date company informed

25.08.06

12. Total holding following this notification

162,395,696

13. Total percentage holding of issued class following this notification

17.24%

14. Any additional information

...............................................................

15. Name of contact and telephone number for queries

Phil Higgins - Assistant Company Secretary

020 7960 2228

16. Name and signature of authorised company official responsible for making this notification

Phil Higgins - Assistant Company Secretary

Date of notification

25.08.06

The FSA does not give any express or implied warranty as to the accuracy of this document or material and does not accept any liability for error or omission. The FSA is not liable for any damages (including, without limitation, damages for loss of business or loss of profits) arising in contract, tort or otherwise from the use of or inability to use this document, or any material contained in it, or from any action or decision taken as a result of using this document or any such material.


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