SOURCE: Active Motif, Inc.

November 19, 2008 05:00 ET

TimeLogic Achieves the Performance of 471 CPU-Cores for HMM Searches Using Single FPGA Accelerator

CARLSBAD, CA--(Marketwire - November 19, 2008) - Active Motif's TimeLogic® division announced that their SeqCruncher™ PCIe accelerator card enables a single server to search hidden Markov model (HMM) databases with the equivalent performance of 471 Xeon CPU-cores.

Search tests were run to compare the performance range, flexibility and scalability of the new SeqCruncher field programmable gate array (FPGA) hardware and improved DeCypherHMM software against the established standard open-source software, HMMER from Dr. Sean Eddy (HHMI). SeqCruncher provided 471x, 863x, and 1151x faster performance per CPU core with 1, 2 and 3 cards when searching an HMM database.

"With one SeqCruncher accelerator installed in a 2 CPU server, we were able to compare 1,000 proteins from the JCVI Global Ocean Sampling Expedition to the Washington University St. Louis Pfam-fs database in 44 seconds. Running HMMER software on the same 8-CPU core server took 43 minutes. This performance makes our system ideal for any laboratory engaged in metagenomics or high-throughput protein annotation," commented Darryl Leon, Ph.D., Product Manager, Informatics at Active Motif.

The SeqCruncher also supports BLAST, Smith-Waterman and gene-modeling tools for bioinformatics, and Active Motif has begun exploring ways to apply this TimeLogic technology to computing burdens relating to next-generation sequencing.

A full report of the SeqCruncher HMM performance details is available online at

About Active Motif, Inc.

Active Motif, founded in 1999, offers research kits, assays and TimeLogic® biocomputing systems to enable scientists to explore the relationships between genes, proteins and metabolic pathways. Active Motif is headquartered in Carlsbad, California, and has international offices in Tokyo, Japan; Brussels, Belgium; and Regensburg, Germany. Press contact: Darryl León, Ph.D. Product Manager, Informatics Active Motif, Inc. tel. 877-222-9543, email:, web site:

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