PETACH-TIKVA, ISRAEL--(Marketwire - Sep 6, 2011) - Aposense Ltd. (
"The full oral bioavailability demonstrated by ATT-11T in animals and the impressive results in pre-clinical efficacy and pharmacokinetic studies demonstrate the potential of this compound and position it favorably for further development," said Yoram Ashery, CEO of Aposense. "Irinotecan (a prodrug of the topoisomerase I inhibitor, SN-38) is a highly potent chemotherapy against solid tumors but its use is limited due to serious adverse reactions. The potential for oral administration, combined with improved efficacy and prolonged pharmacokinetics, may help overcome these limitations."
ATT-11T has been shown in previous animal trials to inhibit and regress tumor growth, and to extend the active drug's blood half-life more than five fold. Animal studies have indicated that ATT-11T is superior to irinotecan in treating various solid tumors.
In addition to its oncology portfolio, Aposense is collaborating with GlaxoSmithKline (GSK) and Roche who are using the company's EarliTest™ for molecular imaging in clinical trials in which the efficacy of new oncological treatments will be tested. In return, Aposense has the right to access and use the resulting imaging data. These clinical trials will be fully funded by GSK and Roche.
About Aposense
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Contact Information:
Contacts:
David Carey
Lazar Partners Ltd.
212-867-1768
dcarey@lazarpartners.com
Dovi Farkash
Aposense
+972-54-9222003
dovi@aposense.com