June 21, 2011 18:19 ET

BPH Research: Enlarged Prostate Treatment Using New Drugs

Dr. David Samadi Comments on the Efficacy and Safety of New Benign Prostatic Hypertrophy (BPH) Treatment Drugs and Possible Increased Risk of High Grade Prostate Cancer

NEW YORK, NY--(Marketwire - Jun 21, 2011) - The FDA recently announced their revision of the Warnings and Precautions labels for 5-alpha reductase inhibitors (5-ARI). These drugs, including finasteride 5mg (Proscar, Propecia) and dudasteride (Avodart), are currently used to treat benign prostatic hyperplasia (BPH) otherwise referred to as enlarged prostate, a non-cancerous prostate disease commonly found in men over the age of 50. Citing new data on a possible increased risk of developing high grade prostate cancer while taking these drugs, the FDA cautioned that doctors should appropriately weigh the benefits against the potential risks in prescribing or continuing to prescribe 5-ARI's for BPH treatment.

This warning was issued after two separate trials found a link between the drugs' usage and the increased incidence of high-grade prostate cancer among participants. "Interestingly, both trials did show a decrease in the overall development of prostate cancer when using these medications," explained Dr. Samadi, Vice Chairman, Department of Urology, and Chief of Robotics and Minimally Invasive Surgery at The Mount Sinai Medical Center. Dr. Samadi is a specialist in prostate cancer treatment, BPH treatment, and robotic surgery. "However, when even a slight increase is shown in the development of deadly forms of prostate cancer, it's imperative that we investigate the use of these drugs for the treatment of BPH."

Fortunately, these drugs are not the only treatment options available for patients with BPH. When indicated, Dr. Samadi often advocates the use of GreenLight Laser PVP (Photoselective Vaporization of the Prostate) or TURP (transurethral resection of the prostate) in the treatment of the condition, in place of 5-ARI's. "With the new information being made available about the dangers that 5-ARI drugs may pose, men taking these drugs should speak with their urologists about the safe and effective surgical options available to them," said Dr. Samadi. "These surgical options have become more advanced, delicate, and effective, with minimal side effects."

Enlarged Prostate (BPH) - Diagnosis and Treatment

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