Human BioSystems
OTC Bulletin Board : HBSC

Human BioSystems

November 02, 2005 07:00 ET

Breaking News: Human BioSystems Breaks New Ground-Successfully Transplants Kidney Frozen for 3 Months

PALO ALTO, CALIFORNIA--(CCNMatthews - Nov. 2, 2005) - Human BioSystems (OTCBB:HBSC) announces today that it was successful in transplanting a rat kidney that had been frozen at a temperature of -80 degreesC for three months in the patent pending HBS Sub-Zero Solution.

"While today's organ preservation technology limits preservation times to only hours, Human BioSystems was able to freeze a rat kidney for 3 months, preserved in the HBS Sub-Zero Solution," stated Dr. Luis Toledo, HBS Chief Medical Officer. "After warming the organ to room temperature the kidney was transplanted into the animal, producing urine for one hour before the animal was sacrificed for further histological tests," continued Dr. Toledo.

The Reperfusion Index (RPI), developed by HBS to indicate a kidney's viability, measured an RPI index score of 14 out of 15 possible in this case, an almost perfect organ. "The excellent RPI score was possible in part because the kidney was able to produce urine even after being frozen for 3 months, which in our opinion is quite remarkable and unprecedented," said Dr. Toledo.

"In order to overcome the damaging effects of freezing, HBS scientists had to limit the expansion of ice to a small fraction of what normally occurs when water freezes. Since the kidney consists primarily of water, this became a very important consideration when freezing an organ," according to Dr. Toledo. "We also had to avoid the harmful effects of crystallization when water turns to ice," Dr. Toledo commented. He further stated that "Both problems were essentially addressed by developing a proprietary solution that not only limits the expansion of water when it turns to ice, but also inhibits the normal crystal formation pattern of ice when the organ is frozen, thereby protecting most of the cells from the damaging effects of the freezing process."

"The results obtained in this experiment show that it is possible to freeze a complex organ such as a kidney for an extended period of time and still maintain its functional characteristics when thawed and transplanted," said Dr. David Winter, HBS President.

Dr. Winter went on to say that "Once human donor organs become more widely available for transplantation, freezing might become a means to bank organs for future use or to allow the time necessary to more optimally match a donor's organ to the recipient. A better donor/recipient match could reduce the need for anti-rejection drugs, which are costly and can be detrimental to the organ recipient over the long term," concluded Dr. Winter.

HBS is headquartered in Palo Alto, California with research facilities in Michigan.

Certain statements contained herein are "forward-looking'' statements (as such term is defined in the Private Securities Litigation Reform Act of 1995). Because such statements include risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Factors that could cause results to differ materially from those expressed or implied by such forward-looking statements include, but are not limited to, results from ongoing research and development as well as clinical studies, failure to obtain regulatory approval for the Company's products, if required, failure to develop a product based on the Company's technology, failure of any such products to compete effectively with existing products, the ability of the Company to fund marketing and sales efforts that may be required to effectively sell its products, and other factors discussed in filings made by the Company with the Securities and Exchange Commission.

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