Chemokine Therapeutics Corp.
TSX : CTI
OTC Bulletin Board : CHKT

Chemokine Therapeutics Corp.

April 30, 2008 08:45 ET

Chemokine Therapeutics Announces Liver Cancer Data Presented at the AACR Meeting on Its Lead Compound, CTCE-9908

VANCOUVER, BRITISH COLUMBIA--(Marketwire - April 30, 2008) - Chemokine Therapeutics Corp. ("Chemokine Therapeutics" or the "Company") (TSX:CTI) (OTCBB:CHKT), a biotechnology company developing chemokine-based therapies to treat cancer, blood disorders, and vascular disease today announced research results which were presented by Dr. Ronnie Poon, from the Department of Surgery, University of Hong Kong at the American Association for Cancer Research (AACR) Annual Meeting. The data showed a strong anti-tumor effect in a preclinical model of liver cancer.

Liver cancer in humans is routinely treated with a combination surgical and chemotherapy procedure called transarterial chemoembolization (TACE). Dr. Poon measured an increase in bone marrow cells in patients with liver cancer one week after TACE therapy. These cells are responsible for repair and regrowth of the tumor after TACE therapy. Dr. Poon showed in his liver cancer animal model that after treatment with a surgical procedure that was equivalent to TACE, the tumor recurred through increasing recruitment of bone marrow support cells and new blood vessel formation. However, when the same surgical procedure was followed by treatment with CTCE-9908, it stopped the re-growth of the tumor. Recruitment of support cells and blood vessels were reduced, the tumor cells died and the tumor eventually disappeared. Treatment with CTCE-9908 also showed a statistically significant increase in survival of approximately 50%, when compared to surgical treatment alone.

"This data demonstrates our understanding of the duel mechanism provided by CTCE-9908 therapy. The compound not only interferes with the dissemination of cancer cells referred to as metastasis but in addition caused a profound decrease in the recruitment of those cells critical to the support and re-growth of a tumor that has been insulted by chemotherapy," stated Walter Korz, President and Chief Executive Officer of the Company. "This data supports the basis for the design of our upcoming Phase II clinical trial in liver cancer."

This poster is available on the Company website at www.chemokine.net.

About CTCE-9908

CTCE-9908 is a peptide analog of the chemokine SDF-1, and an antagonist of its receptor, CXCR4. SDF-1 is the only known naturally occurring chemokine that binds to CXCR4, which is present on many cancer cells as well as cancer support cells such as cells making up new blood vessels. This binding process is believed to be critical to cell migration. The anti-migration property of CTCE-9908 is pivotal in not only reducing recruitment of support cells that allow survival and growth of the primary tumor, but also metastasis (or spread) of cancer cells to distant locations in the body, where they form secondary tumors. Approximately 90% of cancer deaths are due to metastasis and disease progression. We believe that CTCE-9908 has the potential to shrink the primary tumor and delay the occurrence of new tumors due to its anti-angiogenic properties and anti-metastatic activity.

About Chemokine Therapeutics Corp. (TSX:CTI)(OTCBB:CHKT)

Chemokine Therapeutics is a product-focused biotechnology company developing drug candidates in the field of chemokines. Chemokines are a class of signaling proteins that play a critical role in the growth, differentiation, and maturation of cells necessary for fighting infection as well as tissue repair and regeneration. Chemokines also have an important role in cancer metastasis and growth. Chemokine Therapeutics is a leader in research in the field of chemokines and has several products in various stages of development.

Safe Harbor Statement under the U. S. Private Securities Litigation Reform Act of 1995: Statements in this document regarding future expectations, beliefs, goals, plans or prospects constitute forward-looking statements that involve risks and uncertainties, which may cause actual results to differ materially from the statements made. For this purpose, any statements that are contained herein that are not statements of historical fact may be deemed to be forward-looking statements. Without limiting the foregoing, the words "believes", "anticipates", "plans", "intends", "will", "should", "expects", "projects", and similar expressions are intended to identify forward-looking statements. You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause actual results, future circumstances, or events to differ materially from those projected in the forward-looking statements. These risks include, but are not limited to, those associated with the success of research and development programs, the Company's ability to raise additional funding and the potential dilutive effects thereof, the regulatory approval process, competition, securing and maintaining corporate alliances, market acceptance of the Company's products, the availability of government and insurance reimbursements for the Company's products, the strength of intellectual property, reliance on subcontractors and key personnel and other risks detailed from time-to-time in the Company's public disclosure documents and other filings with the U.S. Securities and Exchange Commission and Canadian securities regulatory authorities. Forward-looking statements are made as of the date hereof, and the Company disclaims any intention and has no obligation or responsibility, except as required by law, to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise.

Contact Information

  • Chemokine Therapeutics Corp.
    Mr. Don Evans
    Vice President, Corporate Communications
    (604) 822-0305 or 1-888-822-0305
    (604) 822-0302 (FAX)
    Email: devans@chemokine.net
    Website: www.chemokine.net