NEW YORK, NY--(Marketwired - Apr 30, 2014) - According to a new study from the Johns Hopkins Kimmel Cancer Center, men with evidence of chronic prostate inflammation may be twice as likely to develop prostate cancer as those without. Moreover, the study participants with chronic prostate inflammation were more likely to be diagnosed with high-grade, aggressive prostate cancer.
While the observational study did not demonstrate a clear cause-and-effect relationship between prostate inflammation and cancer, the association was significant enough to warrant further investigation. David Samadi, MD, leading robotic prostate surgeon and Chairman of Urology and Chief of Robotic Surgery at Lenox Hill Hospital, believes the connection could lead to better prostate cancer risk analysis.
"Expanding our understanding of prostate cancer risk factors, expands our opportunity for vigilance over the men most likely to be affected," said Dr. Samadi. "A deeper exploration of the inflammation link may also yield opportunities for prevention and risk mitigation."
Among the 400 study participants, 86.2 percent of overall prostate cancer cases and 88.4 percent of high-grade cases had at least one core biopsy indicating prostate tissue inflammation. Among the men without prostate cancer, prostate inflammation was detected in 78.2 percent of the cases.
The study findings were published in the Journal Cancer Epidemiology, Biomarkers & Prevention on April 18th, http://cebp.aacrjournals.org/content/early/2014/04/14/1055-9965.EPI-13-1126.abstract
Benign prostatic hyperplasia (BPH), commonly diagnosed in men over age 55, is an enlargement of the prostate gland caused by an overgrowth of cells. While BPH is not directly linked to prostate cancer, the close associations between elevated prostate-specific antigen levels (PSA), chronic prostate inflammation, and prostate cancer may now warrant closer attention.
"Prostate inflammation is highly common and men with chronic BPH need not be alarmed of cancer risk," assured Dr. Samadi. "These men have the assurance of regular screenings and attention to their prostate health. That's the biggest prostate cancer prevention strategy we have today."