SOURCE: Crucell N.V.

May 20, 2008 01:45 ET

Crucell Announces Research License Agreement with Bioceros on STAR® Technology

LEIDEN, NETHERLANDS--(Marketwire - May 20, 2008) -


Leiden, The Netherlands, 20 May 2008 - Dutch biopharma company Crucell N.V. (Euronext, NASDAQ: CRXL, Swiss Exchange: CRX) today announced a non-exclusive STAR® research license agreement with Bioceros. The license agreement with the Netherlands based company Bioceros covers the production of monoclonal antibodies. Financial details of the agreement were not disclosed.

About STAR® Technology

STAR® technology is a production technology that is particularly useful for the production of recombinant human antibodies and proteins. It has a potentially broad application and is effective for production of antibodies and proteins on mammalian cell lines such as Crucell's PER.C6® human cell technology and the widely used Chinese hamster ovary (CHO) cell line. STAR® technology contains genetic elements, called STAR® elements, that enable stable and high-yield gene expression important to recombinant antibody and protein production in mammalian cells. The technology has the potential to increase production yields, thereby reducing production costs.

About Crucell

Crucell N.V. (Euronext, NASDAQ: CRXL; Swiss Exchange: CRX) is a global biopharma company focused on research, development, production and marketing of vaccines, proteins and antibodies that prevent and treat primarily infectious diseases. Its vaccines are sold in public and private markets worldwide. Crucell's core portfolio includes a vaccine against hepatitis B, a fully-liquid vaccine against five important childhood diseases and a virosome-adjuvanted vaccine against influenza. Crucell also markets travel vaccines, such as the only oral anti-typhoid vaccine, an oral cholera vaccine and the only aluminum-free hepatitis A vaccine on the market. The Company has a broad development pipeline, with several product candidates based on its unique PER.C6® production technology. The Company licenses its PER.C6® technology and other technologies to the biopharmaceutical industry. Important partners and licensees include DSM Biologics, sanofi-aventis, Novartis, Wyeth and Merck & Co. Crucell is headquartered in Leiden, the Netherlands, with subsidiaries in Switzerland, Spain, Italy, Sweden, Korea and the US. The Company employs over a 1000 people. For more information, please visit www.crucell.com.

About Bioceros

Bioceros is a biotech company focusing on pre-clinical development of protein products, with an emphasis on monoclonal antibodies. Bioceros has a technology platform, consisting of generation of high protein producing CHO cell lines, process development and pre-clinical manufacturing at 20L scale in disposable bioreactors. This is all Quality Controlled, using state of the art serum-free culture media, such that the generated cell lines can be used for GMP manufacturing. In addition, Bioceros has vast experience in pre-clinical development of monoclonal antibodies, including proof of concept and tox studies in animals. Bioceros uses this technology platform:

1. To develop its own pipeline of monoclonal antibody products. The
    first candidate is a monoclonal antibody directed against a
    variant of CD44 (CD44vRA), which is expressed in inflamed tissue
    of RA patients only. This antibody was obtained from MaimoniDex
    Ltd;
 2. To offer services to the industry and academia, including
    generation of high protein producing cell lines, pre-clinical
    manufacturing at 20L scale and consultancy on pre-clinical
    development of monoclonal antibodies. These services have made
    Bioceros financially profitable over the last three years.

Bioceros is located in Utrecht, the Netherlands. For more information, please visit www.bioceros.com.

Forward-looking statements

This press release contains forward-looking statements that involve inherent risks and uncertainties. We have identified certain important factors that may cause actual results to differ materially from those contained in such forward-looking statements. For information relating to these factors please refer to our Form 20-F, as filed with the U.S. Securities and Exchange Commission on May 7, 2008, and the section entitled "Risk Factors". The Company prepares its financial statements under International Financial Reporting Standards (IFRS).

For further information please contact:


Media:                            Investors/Analysts:
Barbara Mulder                    Oya Yavuz
Director Corporate Communications Director Investor Relations
Tel: +31-(0)71-519 7346           Tel: +31-(0)71-519 7064
press@crucell.com                 ir@crucell.com


Bioceros BV:
Remco M. Brandt, M.Sc. (COO)
Yalelaan 46
3584 CM Utrecht
The Netherlands
Tel. +31 (0)30-253 7910
r.brandt@bioceros.com




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