SOURCE: CzechInvest

June 08, 2005 14:17 ET

Czech Scientist Sustain Human Stem Cells in Original 'Blank' State

CzechInvest Announces Czech Scientist Have Made Important Breakthroughs in Stem Cell Research

SAN MATEO, CA -- (MARKET WIRE) -- June 8, 2005 -- CzechInvest, the Investment and Business Development Agency of the Czech Republic, today announced Czech scientists have recently made significant new breakthroughs in stem cell research.

Dr. Petr Dvorak, scientist with the Institute of Experimental Medicine at the Czech Academy of Sciences, will detail the discovery of a potential mechanism that would sustain human stem cells in their original "blank" state. The leading international scientific journal, Stem Cells, is slated to publish these findings in an upcoming issue later this year.

Dvorak says his research suggests embryonic stem cells maintained in a universal or 'totipotent' status can, under certain conditions, be used to develop any type of cells in the human body. Scientists agree this is a key component to realizing the full potential of stem cell therapies.

"We conducted some experiments with our cells, and we think we have discovered some critical mechanism which can be involved in maintaining the cell type in undifferentiated status -- in the status when the cells are really totipotent," Dvorak said.

Other recent Czech breakthroughs in stem cell research include a procedure that uses stem cells to repair the brain and spinal cord. The technique employs nanotechnologies as a labeling-and-delivery mechanism. Credit for this research goes to Professor Eva Sykova, who heads the Czech-based Institute of Experimental Medicine.

Says Sykova: "We have various experiments on animals where we use these stem cells, and we also use biomaterials, like hydrogels, and nanofibers to make scaffolds and all sorts of bridges for the injury in the spinal cord. We also use nanotechnologies. We use them particularly for labeling the stem cells and for following their migration in the tissue and their fate. Also, nanoparticles can be used for the delivery of factors which enhance regeneration."

Dvorak and his team of scientists first gained international recognition in 2003 after they successfully isolated a new line of human embryonic stem cells -- a feat accomplished by only a handful of elite, world-renowned researchers.

The end result of this type of research could evolve into future stem cell therapy that would treat, or even cure, degenerative neurological illnesses such as Parkinson's and Alzheimer's disease, Dvorak said.

According to CzechInvest, Czech scientists are on the cutting edge of stem cell research because their country currently has no laws limiting or restricting human stem cell research. However, all Czech research complies with the Council of Europe's Convention on Human Rights and Biomedicine.

Legislation now under consideration by the Czech Republic's parliament would allow scientists to use stem cells extracted from embryos leftover from fertility treatments. These embryos would otherwise be discarded. Consent from donating couples would be required, and the proposed bill prohibits scientists from creating human embryos specifically to harvest stem cells for research or for cloning.

About CzechInvest

CzechInvest, the Investment and Business Development Agency, is an agency of the Ministry of Industry and Trade. Established in 1992, the agency contributes to attracting foreign investment and developing domestic companies through its services and development programs. CzechInvest also promotes the Czech Republic abroad and acts as an intermediary between the EU and small and medium-sized enterprises in implementing structural funds in the Czech Republic. Visit for more information.

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