DiaMedica Inc.

DiaMedica Inc.

April 19, 2011 17:05 ET

DiaMedica's Type 2 Diabetes Antibody Shown to Increase Glucose Infusion Rate by 291%

WINNIPEG, MANITOBA--(Marketwire - April 19, 2011) - DiaMedica (TSX VENTURE:DMA) today announces positive and important activity with DM-204, its lead monoclonal antibody. In a gold-standard animal model for testing Type 2 diabetes therapies, administration of DM-204 caused a significant increase in glucose utilization. This study in combination with the antibody's recently reported lowering of high blood pressure - the most common complication experienced by diabetes patients - highlight DM-204's potential to become a breakthrough treatment for Type 2 diabetes.

In a preclinical study conducted by Invitech Inc. (Hayward, CA), DM-204's activity was measured using a hyperinsulinemic euglycemic clamp model. Rats acutely treated with a single dose of DM-204 demonstrated a 291% increase in maximal glucose infusion rate (p<0.0035). This significant increase in glucose disposal was associated with a 160% overall average increase (p<0.0066) in the glucose infusion rate in order to maintain euglycemia. DM-204 also showed positive results in two other Type 2 diabetes models.

"DM-204 had a clear effect on whole body glucose utilization," stated Dr. Alan Cherrington, Professor of Medicine at Vanderbilt University, past President of American Diabetes Association, Banting Award winner and member of DiaMedica's scientific advisory board, "I am very keen to see testing of this antibody move forward".

DM-204 was previously reported to reduce blood pressure in an earlier study. High blood pressure (hypertension) is the primary risk associated with Type 2 diabetes, with 70% of Type 2 diabetics at increased risk of stroke and cardiovascular disease as a result of having high blood pressure. As announced on March 2nd 2011, the antibody lowered systolic blood pressure by 15 mmHg (p<0.05).

"These exceptional results of DM-204 for Type 2 diabetes and our earlier hypertension results offer a promising and highly differentiated product," said Mr. Rick Pauls, CEO of DiaMedica. "A monoclonal antibody with potent dual capabilities to normalize blood glucose and blood pressure could replace currently used combination therapies of diabetic and anti-hypertensive drugs. These could be administered as infrequently as once a month. DM-204 has the potential to fundamentally change the treatment regimen for diabetic patients".

About DiaMedica

DiaMedica is a biopharmaceutical company that develops novel therapeutic products designed to improve the lives of people with Type 1 diabetes, Type 2 diabetes and other large, medically unmet diseases. DiaMedica's lead product candidate, DM-199, has been shown to significantly improve glucose metabolism and protect and proliferate beta cells.

The Company is listed on the TSX Venture Exchange under the trading symbol "DMA".


The statements made in this press release that are not historical facts contain forward-looking information that involves risk and uncertainties. All statements, other than statements of historical facts, which address DiaMedica's expectations, should be considered forward-looking statements. Such statements are based on management's exercise of business judgment as well as assumptions made by and information currently available to management. When used in this document, the words "may", "will", "anticipate", "believe", "estimate", "expect", "intend" and words of similar import, are intended to identify any forward-looking statements. You should not place undue reliance on these forward-looking statements. These statements reflect a current view of future events and are subject to certain risks and uncertainties as contained in the Corporation's filings with Canadian securities regulatory authorities. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results could differ materially from those anticipated in these forward-looking statements. The Corporation undertakes no obligation, and does not intend, to update, revise or otherwise publicly release any revisions to these forward-looking statements to reflect events or circumstances after the date hereof, or to reflect the occurrence of any unanticipated events. Although management believes that expectations are based on reasonable assumptions, no assurance can be given that these expectations will materialize.

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