SOURCE: Streetwise Reports

Streetwise Reports

March 31, 2016 09:00 ET

Diffusion Pharmaceuticals' CEO David Kalergis Interviewed by The Life Sciences Report

SAN FRANCISCO, CA--(Marketwired - March 31, 2016) - It takes extraordinary dexterity to execute a strategic merger, and then to take first steps toward positioning a new molecular entity for a Phase 3 drug trial and potential partnership with a big pharma. That's exactly the inflection point at which Diffusion Pharmaceuticals Inc. (OTCQX: DFFN) finds itself, says CEO David Kalergis. In this interview with The Life Sciences Report, Kalergis lays out Diffusion's plan for pivotal development of its treatment for primary brain cancer, which could drive the company's market cap to valuations that would bring huge upside to investors if successful.

The Life Sciences Report : David, let's talk about your clinical program. The Diffusion platform is designed to oxygenate tumor tissues with trans sodium crocetinate prior to conventional therapies. The hypothesis is that oxygenation of the tissues makes tumor cells more vulnerable to radiation and chemotherapy. Does this premise rest on the theory that tumor cells are a) more aggressive in a hypoxic environment, or b) that rapidly proliferating tumor cells are outrunning their blood supply, therefore making them less capable of receiving therapeutic agents via bloodstream?

David Kalergis: What we think is it's "b," which leads to "a." The inherent hypoxic nature of the tumor tissue outgrowing its blood supply then begins to select for more aggressive cells that have evolved to thrive in what would otherwise be an oxygen-deprived, hostile environment. That low-oxygen environment confers treatment resistance on these cancer cells. When you do not have a sufficient amount of free oxygen in the cell to support the killing power of radiation and chemo, those cells that have survived begin to thrive, and they evolve toward a...

Continue reading this interview: Diffusion Pharmaceuticals Takes Aim at Brain Cancer: CEO David Kalergis

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DISCLOSURE:

Diffusion Pharmaceuticals Inc. is a sponsor of Streetwise Reports. David Kalergis had final approval of the content and is wholly responsible for the validity of the statements. Opinions expressed are the opinions of Mr. Kalergis and not of Streetwise Reports or its officers. The interview does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility.

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