SOURCE: Xtalks

Xtalks Webinars

November 03, 2014 07:05 ET

Discover More in Transcriptome Research With the Unprecedented Read Coverage, Sensitivity and Resolution of Targeted RNA Sequencing, Live Webinar Hosted by Xtalks

TORONTO, ON--(Marketwired - November 03, 2014) - In this webinar, the speakers will present a novel targeted RNA sequencing method and elaborate on experiences with targeted RNA sequencing that overcomes many of the standard RNA-Seq limitations and achieves unprecedented read coverage, sensitivity and resolution. Learn more on Wednesday, November 12, 2014 at 3pm EST.

While researchers are currently able to perform whole-transcriptome sequencing (RNA-Seq) to evaluate expression levels, variant splicing events, SNPs, and InDels, the standard RNA-Seq approach has significant drawbacks. A major challenge is that many rare events are not detected due to the depth of sequencing necessary to resolve them whereas the overwhelming number of sequencing reads derive from a small subset of highly abundant transcripts.

Join speakers Dr. Timothy Mercer, Lab Head of Transcriptomic Research at The Garvan Institute of Medical Research, Australia, and Dr. John Tan, Senior Scientist, Sequence Capture at Roche NimbleGen, as they present a novel targeted RNA sequencing method and elaborate on experiences with targeted RNA sequencing that overcomes many of the standard RNA-Seq limitations and achieves unprecedented read coverage, sensitivity and resolution.

Targeted RNA sequencing enables more sensitive gene discovery, more precise measurement of gene abundance, and more accurate isoform assembly. Data will be presented on targeted RNA sequencing to (i) annotate long noncoding RNAs, (ii) profile the expression and aberrant splicing of oncogenes in tumors, (iii) discover new genes in 'empty' disease-associated genome intervals and (iv) map transient RNA intermediates in the splicing pathway. For instance, an analysis of transcription from human chromosome 21 reveals a massive abundance and diversity of splicing, coding and noncoding RNAs, well beyond current annotations. Further comparison to the syntenic mouse transcriptome distinguishes the evolutionary forces shaping this transcriptional and regulatory complexity.

To learn more about this event visit: Discover More in Transcriptome Research with the Unprecedented Read Coverage, Sensitivity and Resolution of Targeted RNA Sequencing

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global Life Sciences community. Every year thousands of industry practitioners (from pharmaceutical & biotech companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

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