SOURCE: Xtalks

Xtalks Webinars

October 02, 2015 07:30 ET

Dynamic Repolarization Analysis: A New Phase I Cardiac Safety Paradigm, New Webinar Hosted by Xtalks

TORONTO, ON--(Marketwired - October 02, 2015) - In this webinar, industry experts Daniel B. Goodman, MD, Vice President and Medical Director, BioTelemetry Research, and Anthony A. Fossa, PhD, Independent Scientific Consultant, will describe ways to enhance the value of early phase cardiac testing. The live broadcast takes place on Wednesday, October 14, 2015 at 11am EDT (4pm BST/ GMT +1).

Continuous data analysis, can be incorporated in dynamic QT beat-to-beat repolarization analysis, examining the ability of the heart to recover from one beat to the next (restitution) in the face of prolongation of the QT interval during rapid heart rates or changes in heart rate (impaired hysteresis).

BioTelemetry Research's innovative Dynamic Repolarization Analysis is best applied within typical SAD and/or MAD studies. Continuous 12-lead Holter recordings, collected during both rest and ambulation, undergo dynamic QT measurement and repolarization analysis to assess the heart's beat-to-beat recovery (restitution) during periods of heart rate acceleration or other changes (impaired hysteresis). Analytical components include:

  • Complete beat-to-beat QT and RR data
  • Continuous QTc profile
  • HR, PR and QRS profiles over time
  • Beat-to-beat QT-RR interval relationship and restitution (QT/TQ vs RR interval)
  • Scatter plots of QT vs RR at baseline and during selected times of treatment (e.g., Cmax)
  • Calculation of % of beats exceeding the upper 97.5% reference bounds for QT interval at baseline
  • Tp-Te values
  • T wave morphology characterization

To learn more about this event visit: Dynamic Repolarization Analysis: A New Phase I Cardiac Safety Paradigm

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global Life Sciences community. Every year thousands of industry practitioners (from pharmaceutical & biotech companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

To learn more about Xtalks visit: http://xtalks.com
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