SOURCE: Xtalks

Xtalks Webinars

October 08, 2014 07:05 ET

Exploring the Extrusion and Spheronization Process, Live Webinar Hosted by Xtalks on Tuesday, October 21, 2014 at 11am EDT (NA) / 4pm BST (UK GMT +1)

TORONTO, ON--(Marketwired - October 08, 2014) -


Extrusion and spheronization is a readily acceptable pharmaceutical process providing several advantages in the development of drug products. Through formulation development, the extrusion and spheronization process allows the ability to administer a drug substance with different release profiles, administer more than one drug substance in a single dosage form, or combine two drug substances with known incompatibilities in a single unit.

Initially, the process calls for wet granulating, or "wet massing" the formulation. The wet mass is added into the extruder where it is forced through a specific sized screen to form cylindrical extrudates. The wet extrudates are added to the spheronizer, equipped with a high speed spinning plate. The high speed "roping" rounds off the cylindrical shapes into uniform spheres. The resultant spheres are dried in a fluid bed dryer and particle size selected by sieve cuts. The spheres may undergo additional processing steps to apply functional or cosmetic coatings using the fluid bed dryer with a Wurster insert. The coated spheres may be used for encapsulation, compression, or direct packaging into sachets or pouches for dosing. This webinar will provide an inside look to Xcelience's capabilities using this technology.

Join keynote speaker Jeff Williamson, Pre-Formulation and Formulation Development Manager at Xcelience, for an informative session that will include a Q&A with the audience.

Key Learning Objectives:
1. Technical advantages of extrusion and spheronization
2. Excipient selection for the extrusion process
3. Examples of process equipment available in the industry, specifically at Xcelience
4. Dosage form examples

To learn more about this event visit: Exploring the Extrusion and Spheronization Process

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global Life Sciences community. Every year thousands of industry practitioners (from pharmaceutical & biotech companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

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Contact Information

  • Contact:
    Michelle Tran
    Tel: +1 (416) 977-6555 ext 352
    Email: mtran(at)xtalks(dot)com