SOURCE: The Obesity Society

The Obesity Society

November 04, 2016 08:00 ET

A Functioning Circadian Clock May Help Maximize Weight Loss Following Bariatric Surgery

Study conducted in mice is one of the first to measure the impact of circadian disruption on bariatric surgery outcomes

NEW ORLEANS, LA--(Marketwired - November 04, 2016) - A newly released basic science study of Roux-en-Y gastric bypass (RYGB) suggests that a functioning circadian clock, or sleeping at night and being awake during the day, can help patients achieve a higher amount of weight loss following the surgery. The study conducted in a mouse model is one of the first to shed light on how researchers and clinicians might continue to improve the outcomes following RYGB by correcting disruptions to the circadian clock. The findings were unveiled during a poster presentation at The Obesity Society Annual Meeting at ObesityWeek℠ 2016 in New Orleans, Louisiana.

Prior research observations suggest that appropriate timing of calorie consumption and minimal disruption of the light/dark cycle set by the environment are crucial for a healthy energy balance and metabolism. However, little is known about the potential role of this molecular clock on maximizing the beneficial metabolic effects of bariatric surgery -- one of the most effective therapies available for obesity.

"Our findings from this mouse study suggest that patients with a disrupted circadian rhythm -- such as night-shift workers and those with night-eating syndrome -- may not be able to achieve the maximum amount of weight loss resulting from bariatric surgery," said the study's lead researcher Mohamad A. Mokadem, MD, ABOM, of the University of Iowa. "Our research shows that it could be important for patients to have a normal circadian clock pre-surgery to maximize weight loss following surgery."

The research implications for patients are drawn from a study conducted in mice, which is one of the first steps toward designing and replicating such a study in humans. Study authors say that more research is needed to better understand the role of circadian rhythm regulators or "clock genes" in the reversal of obesity, including research conducted in a patient population.

"Bariatric surgery has long been recognized as one of the most effective treatments for severe obesity," said Samer Mattar, MD, spokesperson for The Obesity Society and Professor of Surgery at Oregon Health and Science University. "This study is a step toward better understanding the underlying mechanisms affecting bariatric surgery outcomes, enabling us to continue to improve upon this form of treatment."

The Obesity Society reinforces that while bariatric surgery comes with risks, as does any surgery, it is a good option for some -- but not all -- patients.

"There are many options for patients with obesity from surgery to FDA-approved medications and weight-loss counseling," continued Dr. Mattar. "Patients with obesity should discuss their best options with a qualified obesity treatment specialist."

Find additional information and the full abstract here.

This press release can be published in full or in part with attribution to The Obesity Society.

About The Obesity Society
The Obesity Society (TOS) is the leading professional society dedicated to better understanding, preventing and treating obesity. Through research, education and advocacy, TOS is committed to improving the lives of those affected by the disease. For more information visit: www.Obesity.org. Connect with us on social media: Facebook, Twitter and LinkedIn. Find information about industry relationships here.

About ObesityWeek 2016
ObesityWeek is the premier, international event focused on the basic science, clinical application, prevention and treatment of obesity. TOS and the American Society for Metabolic and Bariatric Surgery (ASMBS) host the world's pre-eminent conference on obesity, ObesityWeek 2016, Oct. 31 - Nov. 4, at the Ernest N. Morial Convention Center in New Orleans, Louisiana. For the fourth year, both organizations hold their respective annual scientific meetings under one roof to unveil exciting new research, discuss emerging treatment and prevention options, and network and present. Connect and share with ObesityWeek on Twitter and Facebook, or by using #OW2016.

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