SOURCE: Geneart AG

February 20, 2008 03:30 ET

GENEART is Awarded two US Patents for Successfully Tested HIV Vaccines

REGENSBURG, GERMANY--(Marketwire - February 20, 2008) -

- The US  Patent Office  has awarded  GENEART two  US patents  titled
"Genome of the HIV-1 inter-subtype (C/B') and use thereof"
- The EuroVacc Foundation has successfully tested the protected  gene
sequences in a Phase I trial for use as HIV vaccine
- Further clinical Phase I/II studies of the licensed gene  sequences
have been initiated for 2008 by the EuroVacc Foundation
- These clinical  results underscore  the importance  of the  GENEART
technology for pharmaceutical research

Regensburg, February 20, 2008 - The GENEART AG announces the award of the patents US 7,332,588 and US 7,323,557 titled "Genome of the HIV-1 inter-subtype (C/B') and use thereof" by the United States Patent and Trademark Office. The above-mentioned patents protect the use of specific custom-designed HIV gene sequences for the development as therapeutics or vaccines.

Recently, the now patent-protected gene sequences have been tested as HIV vaccine candidates on 40 test persons by the EuroVacc Foundation in a phase I clinical trial. The trial has turned out to be successful. The results of this study have been published in "The Journal of Experimental Medicine" (Vol. 205, 63-77). In the trial, the prophylactic vaccination proved to be safe and well tolerated, and it triggered a strong and lasting immune response in 90 % of the vaccinated test persons in London and Lausanne. As the licensor, GENEART provided the patented gene sequences (structural design) for the tested vaccines. The synthetic genes were custom-designed by the scientists at GENEART and the University of Regensburg. These genes serve as the basis for the vaccine candidates, which are used in the so-called "prime boost" procedure as naked DNA (DNA-HIV-C), and with a genetically modified small pox vaccine (NYVAC-HIV-C) as a carrier system. The further clinical I/II studies with 120 test persons in Lausanne, London, Paris and Regensburg started already in the beginning of 2008, under the patronage of the European research cluster EuroVacc.

"We take delight in the exceptional results of this clinical trial. Once again, we are looking at convincing proof for the extraordinary value of the GENEART technology platform for pharmaceutical research. The outcome is also a good example for the use of our expertise in a license based business strategy without having to burden GENEART with the financial project risks of clinical trials" explains Professor Dr. Ralf Wagner, CEO of the GENEART AG and Head of the Department for Molecular Microbiology & Gene Therapy at the University of Regensburg.

For further inquiries, please contact:

GENEART AG                       Better Orange IR & HV AG
Josef-Engert-Str. 11             Frank Ostermair
93053 Regensburg                 Haidelweg 48
Germany                          81241 Munich                  Germany
                                 Phone: +49-(0)89-88 96 906-10
Prof. Dr. Ralf Wagner            Fax: +49-(0)89-88 96 906-66
Phone: +49-(0)941-942 76 - 613
Fax: +49-(0)941-942 76 - 711

Bernd Merkl
Manager Investor Relations
Phone: +49-(0)941-942 76 - 638
Fax: +49-(0)941-942 76 - 711

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This document may contain estimates, prognoses and opinions about company plans and objectives, products or services, future results, opinions about these results or opinions leading up to these results. All these projections into the future are subject to risk, uncertainty and unforeseeable change outside the control of the GENEART Group. Many factors may lead to actual results, which considerably deviate from the given projections for these results.


In 2000, GENEART entered the gene synthesis market and has since become the global market leader. Today, the company is one of the leading specialists in the synthetic biology field. Experts at GENEART provide key technologies for the development and production of new therapeutics and vaccines. Customers also take advantage of GENEART services to customize enzyme attributes, such as the attributes of enzymes used as detergent additives, and to construct bacteria, which produce complex biopolymers or break down polymers, such as synthetics, petroleum components, etc. Our production and service spectrum spans a wide range, from the production of synthetic genes according to DIN EN ISO 9001-2000, to the creation of gene libraries in the combinatorial biology, to the development and production of DNA-based biologically active substances. The GENEART AG in Regensburg (Germany) and the subsidiary GENEART Inc. in Toronto (Canada) employ more than 190 people. Since May 2006, GENEART is listed on the German Stock Exchange.

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