SOURCE: Generex Biotechnology

June 13, 2006 09:30 ET

Generex Biotechnology Supported Research Has Podium Presentation at the American Diabetes Association Annual Meeting

TORONTO -- (MARKET WIRE) -- June 13, 2006 -- Generex Biotechnology Corporation (NASDAQ: GNBT) announced today that internationally renowned diabetes investigators Professor Paolo Pozzilli and Dr. Marta Vadacca, both of the Department of Endocrinology and Diabetes at University Campus Bio-Medico, Rome, Italy, made a podium presentation of the results of a research project sponsored by Antigen Express, Inc., a wholly owned subsidiary of the Company, at the 66th Annual Meeting & Scientific Sessions of the American Diabetes Association held June 9 - 13, 2006 in Washington, D.C.

The American Diabetes Association (www.diabetes.org) is the nation's leading nonprofit health organization providing diabetes research, information and advocacy. Founded in 1940, the American Diabetes Association conducts programs in all 50 states and the District of Columbia, reaching hundreds of communities. The mission of the Association is to prevent and cure diabetes and to improve the lives of all people affected by diabetes.

Professor Pozzilli and Dr. Vadacca presented a paper entitled Ii-Key/Insulin MHC Class-II Antigenic Epitope Peptides in Type 1 Diabetes co-authored by Robert E. Humphreys, Nikoletta L. Kallinteris, Luciana Valente, and Giuditta Valorani.

The investigators described the potential of the Antigen Express technologies to more sensitively and accurately diagnose patients with Type 1 diabetes which could lead to the identification of subjects at high risk for the disease. Type 1 diabetes, which occurs in children and young adults, is frequently associated with an autoimmune response to insulin. Using fragments of the insulin protein (peptides) modified by proprietary 'Ii-Key' technologies developed by Antigen Express, it was possible to detect T helper immune cells in the peripheral blood of some patients with recent onset Type 1 diabetes that had developed an aberrant autoimmune response to insulin. Unmodified insulin peptides were inactive in picking up activated T cells. Given that the clinical management of diabetics is different depending on whether or not there is a specific autoimmune response, this technology offers hope for earlier intervention in the management of diabetics to help prevent some of the long-term debilitating effects of diabetes. While not addressed in the current studies, the identification of Ii-Key-modified insulin peptides that are more sensitively recognized by immune cells offers hope for being able to specifically suppress the autoimmune cause of Type 1 diabetes.

About Generex

Generex is engaged in the research and development of drug delivery systems and technologies. Generex has developed a proprietary platform technology for the delivery of drugs into the human body through the oral cavity (with no deposit in the lungs). The Company's proprietary liquid formulations allow drugs typically administered by injection to be absorbed into the body by the lining of the inner mouth using the Company's proprietary RapidMist™ device. The Company's flagship product, oral insulin (Generex Oral-lyn™), which has been approved for commercial sale in Ecuador for the treatment of patients with Type-1 and Type-2 diabetes, is in various stages of clinical trials around the world. Antigen Express is a wholly owned subsidiary of Generex. The core platform technologies of Antigen Express comprise immunotherapeutics for the treatment of malignant, infectious, allergic, and autoimmune diseases.

For more information, visit the Generex website at www.generex.com or the Antigen Express website at www.antigenexpress.com.

Safe Harbor Statement: This release and oral statements made from time to time by Generex representatives concerning the same subject matter may contain "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. These statements can be identified by introductory words such as "expects," "plans," "intends," "believes," "will," "estimates," "forecasts," "projects" or words of similar meaning, and by the fact that they do not relate strictly to historical or current facts. Forward-looking statements frequently are used in discussing potential product applications, potential collaborations, product development activities, clinical studies, regulatory submissions and approvals, and similar operating matters. Many factors may cause actual results to differ from forward-looking statements, including inaccurate assumptions and a broad variety of risks and uncertainties, some of which are known and others of which are not. Known risks and uncertainties include those identified from time to time in the reports filed by Generex with the Securities and Exchange Commission, which should be considered together with any forward-looking statement. No forward-looking statement is a guarantee of future results or events, and one should avoid placing undue reliance on such statements. Generex cannot be sure when or if it will be permitted by regulatory agencies to undertake additional clinical trials or to commence any particular phase of clinical trials. Because of this, statements regarding the expected timing of clinical trials cannot be regarded as actual predictions of when Generex will obtain regulatory approval for any "phase" of clinical trials. Generex claims the protection of the safe harbor for forward-looking statements that is contained in the Private Securities Litigation Reform Act.

Contact Information

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    Shayne Gilliatt
    Generex Biotechnology Corporation
    Phone: (800) 391-6755
    (416) 364-2551

    Andrew Hellman
    CEOcast, Inc.
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