Given Imaging Designates Policlinico A. Gemelli, Catholic University in Rome, as First Colon Capsule Endoscopy Center of Excellence

YOQNEAM, ISRAEL--(Marketwire - Apr 17, 2012) - Given Imaging (NASDAQ: GIVN), a world leader in specialty GI products and pioneer of capsule endoscopy, today announced the designation of the Policlinico Agostino Gemelli in Rome, Italy, as the first colon capsule endoscopy (CCE) Center of Excellence (CoE) in the world. Policlinico A. Gemelli is part of the medical school of the Università Cattolica del Sacro Cuore, the largest private university in Italy. The announcement took place during the EndoLiveRoma 2012, an international endoscopy symposium including live demonstrations and state-of-the-art lectures.

"We are proud that the Policlinico A. Gemelli has been designated as the first colon capsule endoscopy Center of Excellence," said Professor Guido Costamagna, head of the Digestive Endoscopy Unit, Università Cattolica del Sacro Cuore, Policlinico A. Gemelli, Rome. "Over the last four years, we have developed extensive experience in CCE through our participation in several multicenter clinical trials, as well as through academic endeavors such as developing the recently published European Society for Gastrointestinal Endoscopy (ESGE) guidelines on colon capsule endoscopy. We believe that this makes us optimally positioned to educate other clinicians about this valuable diagnostic tool and serve as a reference destination for patients."

"Given Imaging is delighted to designate Policlinico A. Gemelli, an elite health care organization recognized for its high quality patient care, expert medical professionals and support of scientific innovation, as our first Center of Excellence for colon capsule endoscopy," said Homi Shamir, president and CEO, Given Imaging. "Gemelli continues to be a respected source for physician and nurse education regarding colon capsule endoscopy for its colleagues around the world. Such efforts should help to increase awareness about the role and benefits of colon capsule endoscopy in the visualization of colonic mucosa and expand the use of PillCam® COLON 2 in Europe," he added.

Complementary to other colon examinations, PillCam COLON 2 capsule endoscopy is the only non-invasive exam that provides direct visualization for patients where the risks of other modalities could outweigh the benefits. These patients include those who are at a higher risk for complications due to cardiopulmonary disease or use of blood thinning medications. In addition, this new technology could provide a solution for patients that refuse colonoscopy or those with a previous incomplete colonoscopy.

PillCam capsule endoscopes are ingestible video capsules that enable physicians to visualize distinct portions of the GI tract. Patient-friendly in nature, PillCam endoscopy requires no sedation or insufflation and typically is used on an outpatient basis. With PillCam video capsules for the esophagus, small bowel, and colon, PillCam capsule endoscopy has been clinically validated, as evidenced by more than 1,600 peer-reviewed publications. To date, more than 1.5 million patients worldwide have benefited from PillCam endoscopy.

About PillCam COLON 2
The PillCam COLON 2 video capsule is equipped with two miniature color video cameras (one on each end), a battery and an LED light source; it measures 11.6 mm X 31.5 mm. PillCam COLON 2 is designed to be ingested by the patient and transmit up to 35 frames per second for approximately 10 hours to a recording device worn by the patient. Data are transferred from the device to a computer that uses RAPID software to compile the video data and enable the physician to review and report the results of the PillCam study.

All medical procedures carry some risk. The risks of PillCam capsule endoscopy include capsule retention, aspiration, or skin irritation. PillCam COLON 2 capsule endoscopy presents additional risks, including risks associated with the drug products used to prepare the patient for the procedure, which are currently used for colonoscopy, and to move the capsule through the patient's digestive tract faster. It may also present other risks that are unknown. Medical, endoscopic, or surgical intervention may be necessary to address any of these complications, should they occur.

PillCam COLON 2 is not cleared for use in the United States and certain other jurisdictions.

About Agostino Gemelli Teaching Hospital
Agostino Gemelli Teaching Hospital is a large general hospital of 1,850 beds in Rome, Italy. It serves as the teaching hospital for the medical school of the Università Cattolica del Sacro Cuore (the largest privately owned university in Italy, founded in 1921 in Milan), and owes its name to the university founder, the Franciscan friar, physician and psychologist Agostino Gemelli.

About Given Imaging Ltd.
Since pioneering the field of capsule endoscopy in 2001, Given Imaging has become a world leader in GI medical devices, offering health care providers a range of innovative options for visualizing, diagnosing and monitoring the digestive system. The company offers a broad product portfolio including PillCam® video capsules for the small bowel, esophagus and colon, industry-leading ManoScan™ high-resolution manometry and Bravo® wireless and Digitrapper® pH and impedance products. Given Imaging is committed to delivering breakthrough innovations to the GI community and supporting its ongoing clinical needs. Given Imaging's headquarters are located in Yoqneam, Israel, with operating subsidiaries in the United States, Germany, France, Japan, Australia, Vietnam and Hong Kong. For more information, please visit www.givenimaging.com.

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