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March 27, 2008 06:02 ET

High Growth Reported for the World Collagen and HA-Based Biomaterials Market

LONDON, UNITED KINGDOM--(Marketwire - March 27, 2008) - Reportlinker.com announces that a new market research report related to the Surgical material industry is available in its catalogue.

World Collagen and HA-Based Biomaterials Market

This report analyzes the worldwide markets for Collagen and HA-Based Biomaterials in Millions of US$. The major product segments analyzed are Collagen Based Biomaterials (Urinary Incontinence, Corneal Shields, Facial Aesthetic Dermal Implants, & Wound Dressings) and Hyaluronic Acid Based Biomaterials (Viscosupplements, Viscoelastics, & Facial Aesthetic Dermal Implants). The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, and Rest of World. Annual forecasts are provided for each region and product segment for the period of 2000 through 2015. The report profiles 54 companies including many key and niche players worldwide such as Alcon, Inc., Anika Therapeutics, Inc., Bioniche Pharma USA, LLC., Genzyme Biosurgery, Allergan Medical, Q-Med AB, and Seikagaku Corporation. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

CONTENTS

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations I-1

Disclaimers I-2

Data Interpretation & Reporting Level I-2

Quantitative Techniques & Analytics I-3

Product Definitions and Scope of Study I-3

Product Definitions I-3

Collagen Based Biomaterials I-3

Urinary Incontinence I-4

Corneal Shields I-4

Facial Aesthetic Dermal Implants I-4

Wound Dressings I-4

Hyaluronic Acid (HA) I-4

Viscosupplements I-4

Viscoelastics I-4

Facial Aesthetic Dermal Implants I-5

II. EXECUTIVE SUMMARY

1. Market Dynamics II-1

Outlook II-1

Review of Major Segments II-1

Collagen Based Biomaterials II-1

Hyaluronic acid Based Biomaterials II-1

Regional Perspective II-2

Growth Drivers II-2

Challenges Faced II-2

Biomaterials Face Competition II-2

Industry Participants II-3

Leading Players in the Worldwide Collagen Based and HA-Based Biomaterials Market II-3

2. Trends and Issues II-4

Aging Population/Baby Boomers- Play a Major Role II-4

Injectables Market on a High Growth Curve II-4

Skin Care Products Continue to Dominate Cosmeceuticals II-4

Botox and Hyaluronic Acid Replacing Collagen in Facial Implants II-5

Biomaterial Research- Develop New Applications II-5

Potential Shortage of Biomaterials II-5

Reasons for Shortage of Biomaterials II-5

Inadequate Reimbursement Diminish Revenue Growth II-6

3. Biomaterial - A Brief Overview II-7

Definition II-7

Types of Biomaterials for Medical Devices II-7

Polymers II-7

Composites II-7

Metals & Alloys II-7

Ceramics II-8

Biological biomaterials II-8

Applications of Various Forms of Biomaterials II-8

4. Collagen & HA-Based Biomaterials II-9

Collagen Based Biomaterials II-9

What is Collagen? II-9

Collagen-Based Biomaterials II-9

Various Forms of Collagen and Applications II-10

Soft Tissue Fillers Offer Patients More Options II-10

Review of Collagen Dermal Implants Available II-11

Threatened by Alternatives II-11

Hyaluronic Acid (HA) II-11

Table 1: HA Distribution in the Body (includes corresponding Graph/Chart) II-11

Properties of HA II-12

5. Segment Overview II-13

Collagen Based Products II-13

Urinary Incontinence II-13

Definition II-13

Classification of Urinary Incontinence II-13

Stress Incontinence II-13

Urge Incontinence II-13

Overflow Incontinence II-13

Functional Incontinence II-14

Treatment of Urinary Incontinence II-14

Periurethral injections (Collagen Injections) II-14

Collagen Corneal Shields II-14

Research Proceedings II-15

Applications of the Collagen Shields II-15

Ocular Surface Lubrication II-15

Ocular Surface Protection II-15

Drug Delivery II-15

Wound Healing II-15

Facial Aesthetic Dermal Implants II-15

Functions of Collagen-based Facial Implants II-16

Aesthetic Dermal Implants-Playing a Major Role II-16

Normal Skin Changes Associated with Aging II-16

Collagen Injections as Facial implants II-16

Wound Dressings II-16

Leading Players in the Collagen Based Wound Dressing Market II-17

The Global Woundcare Market Flaunts Steady Growth II-17

Other Applications of Collagen II-18

Collagen Gene Delivery Systems II-18

Collagen as Bone Graft Substitution II-18

Artificial Skin II-18

Hyaluronic Acid Based Biomaterials II-19

Viscosupplementation II-19

Hyaluronic Acid as Viscosupplement II-19

Viscosupplementation Treatment for Osteoarthritis II-19

Viscosupplementation - High Rate in Japan II-19

Major Hyaluronic Acid based Viscosupplements II-20

Viscoelastics II-20

Facial Aesthetic Dermal Implants II-20

Commercially Available HA Soft Tissue Fillers II-20

Review of Select HA based Products II-21

Advantages of HA Based Over Collagen Products II-21

Vesicoureteral Reflux Implants II-21

Botox - A Competing Biomaterial II-22

6. Technological Research & Developments II-23

Transgenic Plant Based Recombinant Human Collagen from CollPlant II-23

Composite Cultured Skin from Ortechs II-23

Multi-Gene Method II-23

FortaFlex(TM) Technology II-23

7. Recent Industry Activity II-24

Corgenix and NIDDK Sign CRADA for NASH Research II-24

Orthovita and Allergan Sign a Raw Material Supply Agreement II-24

Warburg Pincus Acquires Bausch & Lomb II-24

Healtheuniverse To Develop Collagen-Based Skin Solutions II-24

Covalon Signs an Agreement with Smith & Nephew II-25

Ortec Seeks PMA for Orcel(R) II-25

Healthpoint Ltd Acquires Biospecifics Technologies Corp II-25

Terumo and Olympus To Start Combined Biomaterial Business II-25

SSC and CMT Inks Exclusive Distribution Agreement II-25

Aastrom and Orthovita Inks Collaboration Agreement II-26

Allergan Acquires Inamed II-26

CollPlant Submits PCT Patent Application II-26

Bioniche Pharma Signs Distribution Agreement with Grunenthal II-27

Lifecore Extends Supply Agreement with Alcon II-27

Inamed and Medicis Terminate Merger Agreement II-27

Genzyme Purchases Synvisc Sales and Marketing Rights from Wyeth II-27

Anika Terminates Partnership with OrthoNeutrogena II-27

Anika Inks Supply Agreement with Bausch & Lomb II-28

Advanced Medical Acquires Pfizer's Ophthalmic Surgical II-28

Q-Med Receives Marketing Licenses II-28

Collagen Matrix Receives NIH Grant II-28

Genzyme Enters the Japanese Hyaluronic Acid Market II-28

Mentor Acquires Two Subsidiaries from Vitrolife II-29

Mentor Acquires Surgical Implants From ProSurg II-29

8. New Launches and Product Approvals II-30

Jarrow Formulas Rolls Out New Products Incorporating BioCell

Collagen II(R) II-30

Medicis' Perlane(R) Obtains US FDA Aprroval II-30

NMT Medical Launches BioSTAR in Canada and Europe II-30

Allergan Releases JUVEDERM ULTRA and JUVEDERM ULTRA PLUS II-31

Laresse Dermal Filler Gets TGA Approval II-31

Veritas (R) Obtains FDA Clearance II-31

Pegasus' DermADAPT(TM) Receives FDA Clearance II-31

Innocoll's CollaGUARD Obtains FDA Approval II-32

PTMC Receives Canadian CMDCAS and European CE Mark Approval II-32

Covalon Receives FDA Approval for Collagran and Collagran Ag II-32

Captique Obtains FDA Approval II-33

Q-MED Introduces RESTYLANE Touch II-33

Genzyme's Hylaform Plus Receives FDA Stamp of Approval II-33

Q-Med's RESTYLANE SubQ Gains CE Certification II-33

Orthovisc Bags FDA Approval for Treatment of Osteoarthritis of the Knee II-33

IDT GmbH Receives CE Certification for Curavisc(R) II-33

Inamed and Genzyme Receives FDA Approval for Hylafor(R) II-34

Inamed Receives FDA Approval for Cosmoderm and Cosmoplast II-34

Vitrolife Receives Approval for Ophthalin II-34

Collagen Matrix Receives Approval for DuraMatrix(TM) II-34

9. Focus on Key Players II-35

Alcon, Inc (US) II-35

Anika Therapeutics, Inc. (US) II-35

Bioniche Pharma USA, LLC (US) II-35

Genzyme Biosurgery (US) II-35

Allergan Medical (US) II-36

Q-Med AB (Sweden) II-36

Seikagaku Corporation (Japan) II-37

10. Global Market Perspective II-38

Table 2: World Recent Past, Current & Future Analysis for Collagen and HA-Based Biomaterials by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010(includes corresponding Graph/Chart) II-38

Table 3: World Long-term Projections for Collagen and HA-Based Biomaterials by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-39

Table 4: World 10-Year Perspective for Collagen and HA-Based Biomaterials by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) II-40

Table 5: World Recent Past, Current & Future Analysis for Biomaterials by Product Groups - Collagen Based and Hyaluronic Acid Based Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-41

Table 6: World Long-term Projections for Biomaterials by Product Groups - Collagen Based and Hyaluronic Acid Based Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-41

Table 7: World 10-Year Perspective for Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based and Hyaluronic Acid Based Markets for Years 2000, 2007 & 2010 II-42

Table 8: World Recent Past, Current & Future Analysis for Collagen Based Biomaterials by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-43

Table 9: World Long-term Projections for Collagen Based Biomaterials by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-44

Table 10: World Recent Past, Current & Future Analysis for Collagen Based Biomaterials by Product Segments - Urinary Incontinence, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-45

Table 11: World Long-term Projections for Collagen Based Biomaterials by Product Segments - Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 includes corresponding Graph/Chart) II-45

Table 12: World 10-Year Perspective for Collagen Based Biomaterials by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) II-46

Table 13: World 10-Year Perspective for Collagen Based Biomaterials by Product Segment - Percentage Breakdown of Dollar Sales for Urinary Incontinence, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) II-46

Table 14: World Recent Past, Current & Future Analysis for Collagen Based Urinary Incontinence by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-47

Table 15: World Long-term Projections for Collagen Based Urinary Incontinence Products by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2011 through 2015 (includes corresponding Graph/Chart) II-48

Table 16: World 10-Year Perspective for Collagen Based Urinary Incontinence by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) II-49

Table 17: World Recent Past, Current & Future Analysis for Collagen Based Corneal Shields by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-50

Table 18: World Long-term Projections for Collagen Based Corneal Shields by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-51

Table 19: World 10-Year Perspective for Collagen Based Corneal Shields by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) II-52

Table 20: World Recent Past, Current & Future Analysis for Collagen Based Facial Aesthetic Dermal Implants by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-53

Table 21: World Long-term Projections for Collagen Based Facial Aesthetic Dermal Implants by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-54

Table 22: World 10-Year Perspective for Collagen Based Facial Aesthetic Dermal Implants by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) II-55

Table 23: World Recent Past, Current & Future Analysis for Collagen Based Wound Dressings by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-56

Table 24: World Long-term Projections for Collagen Based Wound Dressings by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-57

Table 25: World 10-Year Perspective for Collagen Based Wound Dressings by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) II-58

Table 26: World Recent Past, Current & Future Analysis for Hyaluronic Acid Based Biomaterials by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-59

Table 27: World Long-term Projections for Hyaluronic Acid Based Biomaterials by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-60

Table 28: World 10-Year Perspective for Hyaluronic Acid Based Biomaterials by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) II-61

Table 29: World Recent Past, Current & Future Analysis for Hyaluronic Acid Based Biomaterials by Product Segments- Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-62

Table 30: World Long-term Projections for Hyaluronic Acid Based Biomaterials by Product Segments - Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-62

Table 31: World 10-Year Perspective for Hyaluronic Acid Based Biomaterials by Product Segments - Percentage Breakdown of Dollar Sales for Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) II-63

Table 32: World Recent Past, Current & Future Analysis for Hyaluronic Acid Based Viscosupplements by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-64

Table 33: World Long-term Projections for Hyaluronic Acid Based Viscosupplements by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-65

Table 34: World 10-Year Perspective for Hyaluronic Acid Based Viscosupplements by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) II-66

Table 35: World Recent Past, Current & Future Analysis for Hyaluronic Acid Based Viscoelastics by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-67

Table 36: World Long-term Projections for Hyaluronic Acid Based Viscoelastics by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-68

Table 37: World 10-Year Perspective for Hyaluronic Acid Based Viscoelastics by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) II-69

Table 38: World Recent Past, Current & Future Analysis for Hyaluronic Acid Based Facial Aesthetic Dermal Implants by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) II-70

Table 39: World Long-term Projections for Hyaluronic Acid Based Facial Aesthetic Dermal Implants by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) II-71

Table 40: World 10-Year Perspective for Hyaluronic Acid Based Facial Aesthetic Dermal Implants by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) II-72

III. MARKET

1. The United States III-1

A.Market Analysis III-1

The Largest Market III-1

Market Outlook by Segment III-1

Urinary Incontinence Products III-1

Leading Players III-1

Table 41: Leading Players in the US Collagen- Based Urinary Incontinence Implants Market (2004-2006): Percentage Sales Breakdown for Allergan Medical /C.R. Bard, and Others (includes corresponding Graph/Chart) III-2

Corneal Shields III-2

Facial Aesthetic Dermal Implants Highly Competitive III-2

Wound Dressings Market III-2

Viscosupplements Spur Industry Growth III-2

Hyaluronic Acid Knee Procedures on the Rise III-3

Medicare for Viscosupplements III-3

Leading Players III-3

Table 42: Leading Players in the US Viscosupplementation Market (HA based) (2005 &2006): Percentage Share Breakdown by Value Sales for Genzyme, Sanofi, and Others (includes corresponding Graph/Chart) III-4

Viscoelastics III-4

Table 43: Leading Players in the US Viscoelastics # Market (HA based) (2005-2006): Percentage Share Breakdown by Value Sales for Alcon, Advanced Medical Optics, Bausch & Lomb, and Others (includes corresponding Graph/Chart) III-4

Dermal Implants -The Fastest Growing Biomaterial III-5

Trends III-5

US Biomaterials Market Elicits Rosy Future III-5

US - A promising Facial Aesthetic Dermal Implants Market III-5

Enhanced Cosmetic Surgery Procedures to Boost Sales III-5

US Facial Aesthetics Implants- Open Doors for New Players III-6

Table 44: Leading Players in the US Collagen Based Facial Aesthetics Implants Market (2005-2006) III-6

Baby Boomers Trigger Growth III-6

Non-Surgical Cosmetic Procedures in US III-7

Strategic Corporate Developments III-7

Product Launches III-14

Focus on Key Players III-15

Alcon, Inc III-15

Anika Therapeutics, Inc. III-15

Bioniche Pharma USA, LLC (USA) III-16

Datascope Corporation III-16

FibroGen, Inc III-16

Genzyme Biosurgery III-16

Allergan Medical III-17

Isolagen Inc. III-17

Lifecore Biomedical Inc. III-17

B.Market Analytics III-18

Table 45: US Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-18

Table 46: US Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-19

Table 47: US 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010(includes corresponding Graph/Chart) III-20

2. Canada III-21

A.Market Analysis III-21

Strategic Corporate Developments III-21

Product Launches III-22

B.Market Analytics III-23

Table 48: Canadian Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-23

Table 49: Canadian Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-24

Table 50: Canadian 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) III-25

3. Japan III-26

A.Market Analysis III-26

Competitors III-26

Strategic Corporate Developments III-26

Focus on Key Players III-27

Seikagaku Corporation III-27

B.Market Analytics III-27

Table 51: Japanese Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-27

Table 52: Japanese Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-28

Table 53: Japanese 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) III-29

4. Europe III-30

A.Market Analysis III-30

Regional Analysis III-30

Hyaluronic Acid Biomaterials Market in Europe III-30

Table 54: Leading Manufacturers of Viscosupplementation Products in Europe (2006) : Percentage Breakdown by Value Sales for Fidia, Genzyme/Wyeth, Curasan, Seikagaku/Smith & Nephew, and Others (includes corresponding Graph/Chart) III-31

Strategic Corporate Developments III-31

Product Launches III-32

B.Market Analytics III-33

Table 55: European Recent Past, Current & Future Analysis for Collagen and HA-Based Biomaterials by Geographic Region - France, Germany, Italy, UK & Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-33

Table 56: European Long-term Projections for Collagen and HA-Based Biomaterials by Geographic Region - France, Germany, Italy, UK & Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-34

Table 57: European 11- Year Perspective for Collagen and HA-Based Biomaterials by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, Italy, UK & Rest of Europe Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) III-35

Table 58: European Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-36

Table 59: European Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-37

Table 60: European 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) III-38

4a. France III-39

Market Analysis III-39

Table 61: French Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants)Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-39

Table 62: French Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-40

Table 63: French 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) III-41

4b. Germany III-42

A.Market Analysis III-42

Key Player III-42

Curasan AG III-42

B.Market Analytics III-43

Table 64: German Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-43

Table 65: German Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-44

Table 66: German 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) III-45

4c. Italy III-46

Market Analysis III-46

Table 67: Italian Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-46

Table 68: Italian Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-47

Table 69: Italian 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) III-48

4d. United Kingdom III-49

Market Analysis III-49

Table 70: UK Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-49

Table 71: UK Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implant) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-50

Table 72: UK 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) III-51

4e. Rest of Europe III-52

A.Market Analysis III-52

Strategic Corporate Developments III-52

Focus on Key Players III-52

FibroGen Europe Corporation (Finland) III-52

Q-Med AB (Sweden) III-52

B.Market Analytics III-53

Table 73: Rest of Europe Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-53

Table 74: Rest of Europe Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-54

Table 75: Rest of Europe 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) III-55

5. Rest of World III-56

A.Market Analysis III-56

Focus on Key Player III-56

ColBar LifeScience Ltd (Israel) III-56

Recent Industry Activity III-56

B.Market Analytics III-57

Table 76: Rest of World Recent Past, Current & Future Analysis for Collagen and HA-based Biomaterials by Product Groups- Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2000 through 2010 (includes corresponding Graph/Chart) III-57

Table 77: Rest of World Recent Long-term Projections for Collagen and HA-based Biomaterials by Product Segment - Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart) III-58

Table 78: Rest of World 10-Year Perspective for Collagen and HA-based Biomaterials by Product Groups - Percentage Breakdown of Dollar Sales for Collagen Based (Urinary Incontinence Products, Corneal Shields, Facial Aesthetic Dermal Implants and Wound Dressings) and Hyaluronic Acid Based (Viscosupplements, Viscoelastics and Facial Aesthetic Dermal Implants) Biomaterial Markets for Years 2000, 2007 & 2010 (includes corresponding Graph/Chart) III-59

IV. COMPETITIVE LANDSCAPE

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