SOURCE: Xtalks

Xtalks Webinars

October 20, 2014 07:05 ET

Improving the Quality of Allergy and Respiratory Clinical Research Using Induced Sputum Biomarkers, Live Webinar Hosted by Xtalks on Wednesday, October 29, 2014 at 10am EDT (NA) / 2pm GMT (UK) / 3pm CET (EU-Central)

TORONTO, ON--(Marketwired - October 20, 2014) - Both asthma and COPD are highly heterogenic, chronic inflammatory airway diseases. Current treatments such as inhaled corticosteroids, often combined with long-acting bronchodilators, represent the gold standard pharmacotherapy in milder disease; they are much less effective in severe persistent asthma and in COPD. Therefore, as part of a precision approach to drug targeting, inflammatory phenotyping (as one example) may help to identify key inflammatory components within a disease subset both as targets and for monitoring of existing and innovative therapies.

Induced sputum is increasingly being implemented in all phases of drug development both for phenotyping and as a read-out of drug efficacy. The involvement of hundreds of patients undergoing sputum induction requires a multicenter collaboration often spanning countries and continents. The selection of collaborating sites for such large studies poses several methodological, technical and logistical challenges. Standardization and are some of key elements to reduce variability and data loss which if accomplished, can translate into successfully captured outcome measures.

Join presenters Graham Clarke, Senior Director and Head of Respiratory & Inflammation, Quintiles Early Clinical Development, and Neil Alexis, Professor, Department of Pediatrics, Division of Immunology and Infectious Disease, University of North Carolina at Chapel Hill, as they discuss the Quintiles Biospit Initiative, a global effort with collaborating centers aimed at harmonizing methodologies for sputum biomarker collection and testing while also improving site selection and monitoring performance in these trials.

The Quintiles team aims to give you insights into delivering more robust data to enable critical go-no go decisions earlier and with greater confidence in your asthma, COPD, CF, ICF, or other studies.

To learn more about this event visit: Improving the Quality of Allergy and Respiratory Clinical Research Using Induced Sputum Biomarkers

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