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July 16, 2008 14:29 ET

Learn about the Stem Cell Markets

LONDON, UNITED KINGDOM--(Marketwire - July 16, 2008) - Reportlinker.com announces that a new market research report related to the Medical devices industry is available in its catalogue.

Stem Cell Markets

http://www.reportlinker.com/p090979/Stem-Cell-Markets.html

A stem cell is an extraordinary type of cell that has the ability to self-renew for long periods of time and to differentiate into specialized cells under appropriate physiological or experimental conditions. Traditionally, stem cells have been classified as either embryonic, adult (tissue-specific or cord blood) stem cells. Recent understanding of stem cell biology may provide new approaches for the treatment of a number of diseases as well as tissue/organ injuries, including cardiovascular disease, neurological disease, musculoskeletal disease, diabetes and hematopoietic disorders. Stem cell fate is determined by both intrinsic regulators and the extra-cellular environment (niche), and their expansion and differentiation ex vivo are generally controlled by growing them in a specific configuration (monolayer or three-dimensional culture). This process, which is vital to enable stem cells to be used for therapeutic purposes, is called differentiation. Differentiation is a process involving unspecialized cells progressing to become specialized cells with restricted developmental potential. The purpose of this TriMark Publications report is to describe the specific market segments of the medical research space using stem cells for research and development (R&D) purposes. This study reviews all of the generally accepted analytical methods that are currently in use today for preparing and using stem cells. It examines the use of stem cells in developing new therapies for disease.

1. Overview

1.1 Statement of Report

1.2 Scope of the Report

1.3 Methodology

1.4 Executive Summary

2. Biology of Stem Cells

2.1 Scope of this Chapter

2.2 Basic Properties of Stem Cells and Their Classification

2.3 Differentiation of Stem Cells

2.3.1 Neural and Neuronal Differentiation

2.3.2 Cardiomyogenic Differentiation of ESCs

2.3.3 Differentiation of Mesenchymal Stem/Progenitor Cells

2.4 Self Renewal of Stem Cells

2.5 Dedifferentiation and Nuclear Reprogramming

2.6 Functional Proliferation of Adult Mature Cells

2.7 Nanog Promotes Transfer of Pluripotency After Cell Fusion

2.8 MicroRNAs in Stem Cell Development

2.9 Stem Cell Therapy

3. Market Analysis of the Stem Cell Space

3.1 Scope of this Chapter

3.2 The Overall Market Opportunity and Segmentation of the Total Stem

Cell Marketplace

3.3 Potential Stem Cell Commercial Applications

3.3.1 Cord Blood Stem Cells and Cord Blood Stem Cell Banking: Current Market Environment and Opportunity

3.4 Results of Primary Market Survey to Characterize Qualitative and Quantitative Trends in the Stem Cells Space

3.4.1 Characteristics of the Respondent Pool

3.4.2 Utilization of the Different Classes of Stem Cells

3.4.3 Quantitative Metrics of the Stem Cell Research Marketplace: Number of Experiments Performed in Research

3.4.4 Evolution of Research Activities with the Different Types of Stem Cells: Current Usage Trends and Usage in 12 to 18 Months

3.4.5 Types of Research Activities the End-User Community Performs with the Different Types of Stem Cells

3.4.6 Challenges Facing Stem Cell Researchers

3.4.7 Market Drivers and Research Questions Being Addressed in the Stem Cell Space

3.4.8 Summary of Challenges and Opportunities in the Stem Cell Space Based on TriMark's Analysis

3.4.9 Unmet Product Needs in the Stem Cell Research Space and Licensing/IP Constraints

3.5 Competitive Landscape of the Stem Cell Marketplace

3.5.1 SWOT Analysis of the Major Stem Cell Market Segments

3.6 Market Size and Forecasts

4. Worldwide Landscape of Stem Cell Research

4.1 Scope of this Chapter

4.2 Global Embryonic Stem Cell Research

4.2.1 Top Research Institutions Worldwide in the Stem Cells Space and Global "Hot Spots" for Research and Therapeutics

4.3 Stem Cell Research in the U.S.

4.3.1 Proposition 71 in the State of California

4.4 Intellectual Property (IP) Landscape Surrounding Stem Cells

4.5 Who Will Finance Stem Cell Research?

4.5.1 U.S. Government Policy on Stem Cell Research

4.5.2 Current Federal Policy

4.5.2.1 Moral Issues Affecting the Policy

4.5.2.2 Significance and Requirement of Federal Funding

4.5.2.3 Implementing the Current Policy

4.5.3 International Law

4.5.3.1 Australia

4.5.3.2 U.K.

4.5.3.3 Canada

4.5.3.4 China

4.5.3.5 Germany

4.5.3.6 Switzerland

4.5.3.7 Japan

4.5.3.8 Israel

4.5.3.9 Singapore

4.5.4 Technological and Economical Disadvantage for U.S.

5. Therapeutic Areas and Research Programs in the Stem Cell Space

5.1 Scope of this Chapter

5.2 Therapeutic and Other Markets Addressed by Stem Cells

5.2.1 Hematopoietic Stem Cells (HSCs)

5.2.2 Stem Cell Therapeutics for Cardiac and Ischemic Diseases

5.2.3 Stem Cell Therapeutics for Type I Diabetes

5.2.4 Stem Cell Therapeutics for Orthopedic Diseases

5.2.5 Stem Cell Therapeutics for Neurological Disease

5.3 Off-the-Shelf Stem Cells Being Developed

6. Company Profiles

Appendix 1. Glossary of Terms in Stem Cell Biology

INDEX OF FIGURES

Figure 2.1: Derivation of Embryonic Stem Cells (ESCs) from the Inner Cell Mass of Blastocysts

Figure 2.2: Classification of Stem Cells: Embryonic Stem Cells Versus Adult Stem Cells

Figure 2.3: Somatic Cell Nuclear Transfer (SCNT)

Figure 3.1: Segmentation of the Stem Cell Marketplace Based Upon Commercial Offerings-Products and Services

Figure 3.2: Geographical Breakout of Stem Cell End-User Survey Respondents

Figure 3.3: Affiliation (Pharma, Biotech, Academic/University) of Stem Cell End-User Survey Respondents

Figure 3.4: Survey Respondents Are Studying Stem Cells or Using Stem Cells in Their Research

Figure 3.5: Length of Time Survey Respondent Pool Has Been Studying Stem Cells or Using Stem Cells in Its Research Activities

Figure 3.6: Utilization/Research with Different Stem Cell Types

Figure 3.7: Range of Number of Experiments Involving Stem Cells Conducted Per Week

Figure 3.8: Differences with Respect to Usage of Stem Cell Types

Figure 3.9: Research Dollars Spent Monthly on Research/Studies with Different Stem Cell Types

Figure 3.10: Growth of Research Spending in Various Segments of the Stem Cells Space (Defined by Stem Cell Type)

Figure 3.11: Growth in End-User Utilization of the Various Different Stem Cell Types

Figure 3.12: Breakout of the Stem Cell Research Market: Current Research Efforts with Different Types of Stem Cells

Figure 3.13: Breakout of the Stem Cell Research Market: Research Efforts with Different Types of Stem Cells in 12 to 18 Months

Figure 3.14: Broad Classification of Research Activities Being Performed with Stem Cells by Researchers

Figure 3.15: Current End-User Utilization Category of Adult Stem Cells (ASCs)

Figure 3.16: Current End-User Utilization Category of Human Embryonic Stem Cells (hESCs)

Figure 3.17: Current End-User Utilization Category of Human Cord Blood Stem Cells

Figure 3.18: Current End-User Utilization Category of Animal Stem Cells

Figure 3.19: Current End-User Utilization Category of Cancer Stem Cells

Figure 3.20: Challenges in the Study or Utilization of Adult Stem Cells (ASCs)

Figure 3.21: Challenges in the Study or Utilization of Human Embryonic Stem Cells (hESCs)

Figure 3.22: Challenges in the Study or Utilization of Human Cord Blood Stem Cells

Figure 3.23: Challenges in the Study or Utilization of Animal Stem Cells

Figure 3.24: Challenges in the Study or Utilization of Cancer Stem Cells

Figure 3.25: Top Unmet Needs in Commercial Products in the Stem Cell Research Space

Figure 3.26: The U.S. Stem Cell Therapy Market Sales, 2005-2016

Figure 4.1: Stem Cell Research Worldwide

INDEX OF TABLES

Table 2.1: The Different Types of Stem Cells and Their Properties

Table 2.2: Adult Stem Cell (ASC) Differentiation Properties

Table 3.1: Characteristics of Different Stem Cell Types and Associated Market Opportunity

Table 3.2: Segmentation of the Stem Cell Market by Type/Lineage of Stem Cells

Table 3.3: Selected Cord Blood Banks in the U.S.

Table 3.4: Selected Companies in the Cord Blood Stem Cell Technology and Therapeutics Development Space

Table 3.5: Breakout of the Stem Cell Research Market: Current Research Efforts with Different Types of Stem Cells

Table 3.6: Breakout of the Stem Cell Research Market: Research Efforts with Different Types of Stem Cells in 12 to 18 Months

Table 3.7: Market Share of Companies/Institutions Offering Different Stem Cells to Researchers

Table 3.8: Market Share of Companies/Institutions Offering Reagents for Stem Cell Research

Table 3.9: The U.S. Stem Cell Therapy Market Forecast, 2005-2016

Table 3.10: The World Market for Stem Cell Products and Services, 2005-2012

Table 4.1: Major Milestones in Stem Cell Research and Associated Timeline, 1981-2008

Table 4.2: Selected Stem Cell Hot Spots Worldwide Administering Non-FDA Approved Stem Cell Therapeutic Regimens

Table 4.3: NIH Funding of Stem Cell Research in the U.S., 2004-2009

Table 4.4: Snapshot of the Current Key Stem Cell Patents

Table 4.5: Stem Cell Derivations

Table 5.1: Estimate of Potential Market Opportunity for Stem Cell-based Therapeutics

Table 5.2: Autologous Versus Allogeneic Cell Therapy

Table 5.3: Diseases Treated with HSC Transplantation Today

Table 5.4: HSC Sources and Their Properties

Table 5.5: Stem Cell Therapeutics for Hematological Diseases in Development

Table 5.6: Stem Cell-based Therapeutics for Cardiac and Ischemic Diseases in Development

Table 5.7: Stem Cell-based Therapeutics for Vascular Diseases in Development

Table 5.8: Stem Cell Therapeutics for Type I Diabetes in Development

Table 5.9: Stem Cell Therapeutics for Orthopedic Disease in Development

Table 5.10: Stem Cell Therapeutics for Neurological Disease in Development

Table 5.11: Segmentation of the Allogeneic Cell Therapy Market

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Stem Cell Markets

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