SOURCE: Living Cell Technologies

October 22, 2007 08:30 ET

Living Cell Technologies Reports Further Positive Preliminary Data on DiabeCell® Phase I/IIa Trial

MELBOURNE, AUSTRALIA and AUCKLAND, NEW ZEALAND--(Marketwire - October 22, 2007) - Living Cell Technologies Limited (ASX: LCT) (PINKSHEETS: LVCLY) today released an update on the initial responses observed in its ongoing DiabeCell® clinical trial.

Medical Director of Living Cell Technologies, Professor Bob Elliott, advised that two patients have been implanted with their first dose of DiabeCell® and are due for a second dose six months later.

The first patient was injected with his first dose in June 2007, without adverse effects. Control of blood glucose levels has been maintained, while his daily insulin requirement was gradually reduced by about 40% over the past four months.

The second recipient was implanted with her first dose of DiabeCell® in September 2007, without adverse effects and control of blood glucose has been maintained with progressive reduction of daily insulin requirements. At one month following the implant, this patient has been weaned off insulin altogether.

"These early stage results have exceeded our expectations, with one patient no longer dependant on insulin therapy following the smallest dose of DiabeCell®," said Professor Elliot.

Living Cell Technologies Chief Executive Officer Dr. Paul Tan commented: "This promising result increases the prospects of DiabeCell® as an effective commercial treatment for diabetes."

The object of the phase I/IIa trial is to determine whether a small dose of live micro-encapsulated pig islets injected into the abdominal cavity of type 1 diabetic patients is safe and can produce enough insulin to have a measurable effect on improving the control of blood glucose levels.

In the trial at the Sklifasovsky Institute in Moscow, each of six patients is to receive two transplants of the smallest dose, 5,000 islet equivalents (IEQs), which is equivalent to one third of the maximum dose (15,000 IEQs) planned for testing in the Company's proposed New Zealand clinical trial.

The Company cautioned that the data is very preliminary and should be interpreted in the context of complete data that will be accrued from the remainder of the trial.

Further information on the Company's current clinical trial is available at

About Living Cell Technologies:

Living Cell is developing cell-based products to treat life-threatening human diseases. The Company owns a biocertified pig herd that it uses as a source of cells for treating diabetes and neurological disorders. For patients with Type 1 diabetes, the Company transplants microencapsulated islet cells so that near-normal blood glucose levels may be achieved without the need for administration of insulin or at significantly reduced levels. The company entered clinical trials for its diabetes product in 2007. For the treatment of Huntington's disease and other neurological disorders, the company transplants microencapsulated choroid plexus cells that deliver beneficial proteins and neurotrophic factors to the brain. Living Cell's technology enables healthy living cells to be injected into patients to replace or repair damaged tissue without requiring the use of immunosuppressive drugs to prevent rejection. Living Cell also offers medical-grade porcine-derived products for the repair and replacement of damaged tissues, as well as for research and other purposes.

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Contact Information

  • Contacts:

    Richard Justice
    Chief Financial Officer
    Tel: +64-9-276-2690 (x. 739)
    Mobile: +64-21-223-4741

    Dr. Paul Tan
    Chief Executive Officer
    Tel: +64-9-270-7941
    Mobile: +61-402-716-984

    Rachel Levine
    Investor and Media Relations
    Tel: +646-284-9439