TORONTO, ONTARIO--(Marketwired - April 4, 2014) - Lorus Therapeutics Inc. (TSX:LOR) today announced it will present preclinical data for LOR-253 in acute myeloid leukemia (AML) and other hematologic cancers at the American Association for Cancer Research (AACR) Annual Meeting 2014, to be held at the San Diego Convention Center in San Diego, CA, April 5-9, 2014.
LOR-253, the company's lead anti-cancer agent, is a clinical-stage, small molecule therapeutic that acts through induction of the innate tumor suppressor Krüppel-like factor 4 (KLF4). Lorus is currently pursuing the clinical development of LOR-253 in AML based on recent research that has implicated up-regulation of various transcription factors, including CDX2, as a causative gene in the development or progression of leukemic disease. The CDX2 protein has been shown to silence the KLF4 tumor suppressor gene, reported to be a critical oncogenic event in AML. LOR-253 is the only clinical-stage agent to act through the induction of KLF4 and may represent a novel approach for the treatment of AML and other hematologic malignancies.
In a prior single-agent, Phase I clinical study, LOR-253 demonstrated antitumor activity and a robust safety profile in patients with solid tumors.
At the 2014 AACR meeting, Lorus researchers will present preclinical data on the effect of LOR-253 in acute myeloid leukemia and other blood cancer cell lines:
Poster presentation: Induction of KLF4 by LOR-253 as an innovative therapeutic approach to induce apoptosis in acute myeloid leukemia
- Tuesday, April 08, 2014, 1:00 PM - 5:00 PM PDT
- Location: Hall A-E, Poster Section 31, Poster Board #3
- Abstract #4544
Lorus is a clinical-stage biotechnology company with a commitment to discovering and developing targeted therapies addressing unmet medical needs in oncology. We aim to develop therapeutics focused on novel cellular targets on the leading edge of cancer research coupled to companion diagnostics to identify the optimal patient population for our products. Our pipeline of cancer drug candidates includes small molecule products and immunotherapies providing additive or synergistic efficacy without leading to overlapping toxicities with existing anti-cancer regimens, facilitating the adoption of doublet or possibly triplet therapies. Lorus Therapeutics Inc. is listed on the Toronto Stock Exchange under the symbol LOR.
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