SOURCE: Marina Biotech, Inc.

Marina Biotech, Inc.

April 04, 2011 08:30 ET

Marina Biotech Presents Long Term Toxicology Data for CEQ508 FAP Drug Candidate

Company to Present at the American Association for Cancer Research (AACR) Annual Meeting

BOTHELL, WA--(Marketwire - April 4, 2011) - Marina Biotech, Inc. (NASDAQ: MRNA), a leading RNAi-based drug discovery and development company, today announced its presentation of long term toxicology data at the 102nd AACR Annual Meeting. An initial analysis of the results of the recently completed CEQ508 long-term toxicology study in non-human primates identified the preliminary No Observed Adverse Effect Level (NOAEL) as 1x1011 colony forming units (cfu)/day, the highest dose administered in the toxicology study as well as the highest dose anticipated in the Dose Escalation Phase of the human clinical trial. The poster presentation titled "Long term safety observed with CEQ508: An oral RNAi drug targeting β-catenin of GI polyps" will be presented by Alison Silva, Vice President, Drug Development at Marina Biotech on Monday, April 4 from 1:00 to 5:00pm at the Orange County Convention Center in Orlando, Florida.

"We're very pleased to be presenting this look at the safety data from our non-human primate study," stated J. Michael French, President and CEO at Marina Biotech. "This study establishes a very strong safety profile supporting the long-term and daily use of our orally administered Familial Adenomatous Polyposis (FAP) therapeutic candidate. As we advance further into clinical development, the results of this study will be used to determine the duration and design of our Phase 2b trial. With the recent announcement of first-in-man patient enrollment in the START-FAP (Safety and Tolerability of An RNAi Therapeutic in FAP) trial, we continue to execute on our clinical and regulatory plan to commercialize this product by 2014."

About CEQ508

CEQ508 is the first drug candidate in a novel class of therapeutic agents utilizing the transkingdom RNA interference (tkRNAi) platform. CEQ508 comprises attenuated bacteria that are engineered to enter into dysplastic tissue and release a payload of short-hairpin RNA (shRNA), a mediator in the RNAi pathway. The shRNA targets the mRNA of β-catenin, which is known to be dysregulated in classical FAP. CEQ508 is being developed as an orally administered treatment to reduce the levels of β-catenin protein in the epithelial cells of the small and large intestine. Upon enrollment, patients will be placed in one of four dose-escalating cohorts. Following completion of the dose escalation phase, the trial plan calls for a stable-dose phase in which additional patients will receive the highest safe dose. CEQ508 will be administered daily in an oral suspension for 28 consecutive days. For more information please contact clinicaltrials@marinabio.com

About FAP

CEQ508 is being developed for the treatment of Familial Adenomatous Polyposis (FAP), a hereditary condition that occurs in approximately 1:10,000 persons worldwide. FAP is caused by mutations in the Adenomatous Polyposis Coli (APC) gene. As a result of these mutations, epithelial cells lining the intestinal tract have increased levels of the protein β-catenin, which in turn, results in uncontrolled cell growth. Proliferation of the epithelial cells results in the formation of numerous (hundreds to thousands) non-cancerous growths (polyps) throughout the large intestine. By age 35, 95% of individuals with FAP have developed polyps and most will experience adverse effects including increased risk of bleeding and the potential for anemia. In more severe cases, obstruction of the intestines, abdominal pain, and severe bouts of diarrhea or constipation can occur. FAP patients are also at an increased risk of various cancers, the most concerning of which is a nearly 100% occurrence of colon cancer if measures are not taken to prevent the formation of polyps. For many patients, complete colectomy (surgical removal of the entire large intestine), usually performed in the late teenage years or early twenties, is the only viable option for treatment. However, surgical intervention is not curative as the risk of polyps forming in the remaining portions of the intestinal tract and in the small intestine continues after colectomy.

About Marina Biotech, Inc.
Marina Biotech is a biotechnology company, focused on the development and commercialization of RNA interference- (RNAi) and RNA-based therapeutics. The Marina Biotech pipeline currently includes a clinical program in Familial Adenomatous Polyposis (a precancerous syndrome) and two preclinical programs -- in hepatocellular carcinoma and bladder cancer. Marina Biotech has recently entered an exclusive agreement with Debiopharm Group for the development and commercialization of the bladder cancer program. Marina Biotech's goal is to improve human health through the development of RNAi and RNA-based compounds and drug delivery technologies that together provide superior therapeutic options for patients. Additional information about Marina Biotech is available at http://www.marinabio.com.

Forward-Looking Statements

Statements made in this news release may be forward-looking statements within the meaning of Federal Securities laws that are subject to certain risks and uncertainties and involve factors that may cause actual results to differ materially from those projected or suggested. Factors that could cause actual results to differ materially from those in forward-looking statements include, but are not limited to: (i) the ability of Marina Biotech to obtain additional funding; (ii) the ability of Marina Biotech to attract and/or maintain manufacturing, research, development and commercialization partners; (iii) the ability of Marina Biotech and/or a partner to successfully complete product research and development, including preclinical and clinical studies and commercialization; (iv) the ability of Marina Biotech and/or a partner to obtain required governmental approvals; and (v) the ability of Marina Biotech and/or a partner to develop and commercialize products that can compete favorably with those of competitors. Additional factors that could cause actual results to differ materially from those projected or suggested in any forward-looking statements are contained in Marina Biotech's most recent periodic reports on Form 10-K and Form 10-Q that are filed with the Securities and Exchange Commission. Marina Biotech assumes no obligation to update and supplement forward-looking statements because of subsequent events.

Contact Information

  • Contacts:

    Marina Biotech, Inc.
    Peter Garcia
    Chief Financial Officer
    (425) 908-3603
    Email Contact

    Alison Silva
    Vice President, Clinical Development
    (617) 995-7943
    Email Contact