SOURCE: Market Pulse

May 02, 2005 08:25 ET

Market Pulse Breaking News Alert for Monday, May 2, 2005: BIPH - Biophan Identifies a Major Cause of Pacemaker Heating Controversy!

NOTE TO EDITORS: The Following Is an Investment Opinion Being Issued by Market Pulse.

ATLANTA, GA -- (MARKET WIRE) -- May 2, 2005 -- Market Pulse News Alert for this AM, Stocks to Watch are: Biophan Technologies, Inc. (OTC BB: BIPH), Martek Biosciences Corp. (NASDAQ: MATK), Sun Microsystems Inc. (NASDAQ: SUNW), and Siebel Systems Inc. (NASDAQ: SEBL).

Investors need to be watching Biophan Technologies, Inc. (OTC BB: BIPH) this AM! Biophan develops and markets cutting-edge technologies designed to make biomedical devices safe and compatible with the magnetic resonance imaging (MRI) environment. Biophan's technology is also being used to create MRI contrast agents, and has expanded to include other applications, such as drug delivery and power systems derived from body heat. Biophan has joint development arrangements with Boston Scientific and NASA's Ames Center for Nanotechnology. BIPH has had several excellent news announcements lately and one again after Friday's bell announcing they have identified a major cause of pacemaker heating controversy! Investors should be watching this one closely!

Biophan Technologies, Inc. (OTC BB: BIPH), a developer of next-generation medical technology, today announced the results of its recent scientific studies that help to explain the widely varying reports on the Magnetic Resonance Imaging (MRI) safety of implanted medical devices such as pacemakers, defibrillators, neurostimulators, and other devices. These important findings, disclosed in part today on Biophan's website, will be a subject of discussion with multiple medical device manufacturers next week at the Heart Rhythm Society annual meeting in New Orleans.

Michael Weiner, CEO of Biophan Technologies, stated that "Five years ago, Biophan was founded to solve the problems of pacemaker heating which have precluded millions of pacemaker patients from undergoing MRI, including for critical needs such as preparation for cancer treatment. Over the last several years, the worldwide scientific community has been divided over whether there is or is not a real safety problem. Biophan has identified a major inconsistency in the method of testing used by the industry to assess pacemaker heating during MRI, which helps to account for the wide variation of results observed in lead heating."

Biophan results revealed today indicate that some of the unintentional variance seen in testing is due to limitations in the methods of testing and the very complicated physics associated with MRI. Biophan has worked for several years with some of the leading industry experts to better understand MRI-induced heating phenomena at the critical pacemaker-tissue interface.

Biophan scientists have characterized a wide array of variables related to devices, patients, MRI scan parameters, and temperature measurement techniques that can affect lead heating. For example, testing has determined that maximum heating occurs slightly into the tissue and not at the tip of the electrode where heating is typically measured, and that different types of approved temperature measurement probes can significantly understate actual heating due to their design.

When more accurate and more precise temperature measurement protocols are used, physiologically significant temperature increases well in excess of currently allowable limits are observed.

To view graphs depicting the results of these experimental studies, please visit http://www.biophan.com/042905MRISafety.htm.

The data released today reveal some of the results from Biophan's recent experimental studies. This data include studies of the temperature generated by a device and its dependence upon the location of the patient and device within the MRI scanner. Moving the pacemaker lead as little as 3 to 4.3 inches within the scanner can result in an increase in temperature at the tip of the lead of over 10 degrees Celsius, enough to cause significant tissue damage. This could occur clinically as a result of shifting a patient off center in the MRI bore to better image other tissues.

Additional data, available on the Company's website, shows the effect of two different temperature probe designs, both of which are acceptable according to the current ASTM testing standard. This information is significant since it also affects the way MRI-induced heating is measured in other devices, such as the safety testing of surgical tools used in the emerging field of MRI-guided interventional medicine.

Biophan will be attending this year's Heart Rhythm Society Conference at a very critical period in the rapid growth of MRI. Pacing and Clinical Electrophysiology ("PACE") magazine, the official journal of the international cardiac pacing and electrophysiology society, recently published a diverse array of industry and FDA opinions on the potentially life-threatening issue of the safety of pacemakers and other implanted medical devices in MRI.

Michael Weiner stated, "We were pleased to see this information in the recent PACE magazine editorials and articles. We are particularly pleased to see recognition both by key industry and government experts, sharing our view that MRI safety cannot be guaranteed until devices are designed from the ground up, with rigorous scientific testing."

The Heart Rhythm 2005 conference is organized by the Heart Rhythm Society and will be attended by top research professionals and medical device executives from the United States, Europe, and Asia. For further information on the conference, please visit http://www.heartrhythm2005.org/index.asp

About the Heart Rhythm Society

Heart Rhythm Society, incorporated in 1979, has a membership of approximately 3,500 physicians and associated professionals from the United States, Canada, Mexico and many other countries. Heart Rhythm Society is the dominant professional group representing the allied specialties of cardiac pacing and cardiac electrophysiology in North America and plays an important role not only in education but also as an intermediary between government regulatory agencies and members of the profession. Heart Rhythm Society offers Annual Scientific Sessions which include core curricula, symposia, clinical tutorials, meet-the-expert panels, mini-courses, Young Investigator presentations, debates, and state-of-the-art scientific abstracts. For more information, please visit www.hrsonline.org

About Biophan Technologies

Biophan develops and markets cutting-edge technologies designed to make biomedical devices safe and compatible with the magnetic resonance imaging (MRI) environment. The Company develops enabling technologies for implanted medical systems such as pacemakers and interventional surgical devices such as catheters, guidewires, stents, and other implants to allow them to be safely and effectively imaged under MRI. The technology is also being used to create MRI contrast agents, and has expanded to include other applications, such as drug delivery and power systems derived from body heat. Four Biophan technologies include advances in nanotechnology and thin film coatings. Committed to growth through innovation and developmental leadership, Biophan and its licensors now hold a total of 114 U.S. patents, licenses, or applications. This total includes 36 issued U.S. patents, 6 recently allowed applications that will issue as patents in the near future, and 72 pending applications at various stages of examination at the U.S. Patent and Trademark Office, plus international applications. The patents cover areas including nanotechnology (nanomagnetic particle coatings), radio frequency filters, polymer composites, thermoelectric materials for batteries generating power from body heat, and photonics. Biophan has joint development arrangements with Boston Scientific and NASA's Ames Center for Nanotechnology. Biophan's goal is to make all biomedical devices capable of safely and successfully working with MRI, and delivering other technologies which will improve quality of life. For more information, please visit www.biophan.com.

Stocks acting well as of late include: Martek Biosciences Corp. (NASDAQ: MATK), Sun Microsystems Inc. (NASDAQ: SUNW), and Siebel Systems Inc. (NASDAQ: SEBL).

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