SOURCE: Xtalks

Xtalks Webinars

February 10, 2015 07:05 ET

Measuring Cell-Mediated Immunity in Clinical Trials With Multiparametric Flow Cytometry

A Case-Study Using Plant-Derived Virus-Like Particles (VLP) in Influenza Vaccines, New Webinar Hosted by Xtalks

TORONTO, ON--(Marketwired - February 10, 2015) - In this scientific webinar, industry experts Stéphane Pillet, PhD., Immunology Scientist at Medicago Inc. and Jean-Francois Poulin, PhD., Senior Principal Scientist at Caprion/IMMUNECARTA Services will describe how the production of Virus-Like Particle (VLP)-based vaccines using plant-based transient expression technology has particular advantages for accelerating both the development of new influenza vaccines and the scaling-up of production for deployment in affected areas, and how state-of-the-art multiparametric flow cytometry is used to monitor cell-mediated immunity at the phenotypic and functional level within the context of a clinical trial.

Vaccine lots, which exactly match the specific strain(s) in circulation can be generated within a month of strain identification. This is a significant improvement compared to more traditional fertilized chicken egg-based platforms, which require half a year or more for viral strain production. Plant-based VLP technology is rapid, scalable and relatively low-cost, with the added safety advantage that the VLP contains no genetic material, rendering it non-infectious and unable to replicate.

Although hemagglutination inhibition (HI) antibody titers is the universally accepted immune correlate of protection against influenza, recent studies indicate that it does not necessarily translate into protection, and clinical benefit may be short-lived, particularly in the elderly. Recent animal data have suggested that in situations where antibodies fail to confer protection, cell-mediated immunity may be able to act alone, indicating that some shortcomings currently associated with influenza vaccines might be surmounted via use of novel vaccines which elicit CD4 and CD8 T cell responses.

Case study data from a current clinical immune monitoring study will be presented, showing how the specificity and magnitude of CD4 and CD8 T cell responses were measured following immunization, using multiparametric flow cytometry and related analytical tools to monitor the distribution of Influenza-specific cellular subsets both at the phenotypic and functional level.

Join the live broadcast on Tuesday, February 17, 2015 at 11am EST (4pm GMT). The 60-minute presentation will include a Q&A session with the audience. To learn more about this event visit: Multiparametric Flow Cytometry Analysis of Cell-mediated Immunity in Clinical Trials

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global Life Sciences community. Every year thousands of industry practitioners (from pharmaceutical & biotech companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

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