MARTINSRIED, GERMANY and MUNCHEN, GERMANY--(Marketwired - Apr 26, 2013) - MorphoSys AG /
MorphoSys Initiates Phase 2 Study of Anti-CD19 Antibody MOR208 in B-cell
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MorphoSys AG (FSE: MOR; Prime Standard Segment; TecDAX) announced today
has dosed the first patient in a Phase 2 clinical trial of MOR208 in
acute lymphoblastic leukemia (B-ALL). MOR208 is a potent monoclonal Fc
anti-CD19 antibody to which MorphoSys gained worldwide access via an
license and collaboration agreement with Xencor in 2010.
The US-based study is an open-label, multicenter, single-arm clinical
designed to assess the efficacy of MOR208 in patients suffering from
refractory B-ALL. Secondary outcome measures include response duration,
and pharmacokinetics of MOR208. In total, 30 patients are planned
enrolled. More information on the trial can be found by searching for
"Due to its high expression levels on non-Hodgkin's lymphomas and
leukemias CD19 represents a particularly attractive immunotherapy
hematological cancers," commented Dr. Arndt Schottelius, Chief
Officer of MorphoSys AG. "What is unique about MOR208 is that the
comprises only a very minor change to the Fc part of the molecule
significantly increased potency."
MOR208 has shown in a Phase 1/2a trial encouraging signs of preliminary
anti-tumor activity and an acceptable safety and tolerability profile
with high-risk, heavily pretreated chronic lymphocytic leukemia (CLL) or
lymphocytic lymphoma (SLL). In addition to the Phase 2 trial in B-ALL
is about to start a second Phase 2 trial in Non-Hodgkin's Lymphoma (NHL).
B-cell malignancies, such as B-ALL, NHL and CLL affect more than one
fifty thousand patients in the seven major markets each year. The
molecule CD19 is expressed more broadly and earlier in B-cell development
CD20, the target of the marketed cancer drug Rituxan®. Therefore
CD19 could potentially allow for an even broader therapeutic use of MOR208
marketed anti-CD20 antibodies.
MorphoSys developed HuCAL, the most successful antibody library technology
the pharmaceutical industry. By successfully applying this and other
technologies, MorphoSys has become a leader in the field of therapeutic
antibodies, one of the fastest-growing drug classes in human healthcare.
Together with its pharmaceutical partners, MorphoSys has built a
pipeline of more than 70 human antibody drug candidates for the treatment
cancer, rheumatoid arthritis, and Alzheimer's disease, to name just a few.
its ongoing commitment to new antibody technology and drug development,
MorphoSys is focused on making the healthcare products of tomorrow.
listed on the Frankfurt Stock Exchange under the symbol MOR. For regular
about MorphoSys, visit http://www.morphosys.com.
HuCAL®, HuCAL GOLD®, HuCAL PLATINUM®, CysDisplay®,
Ylanthia® and 100 billion high potentials® are registered
Slonomics® is a registered trademark of Sloning BioTechnology
subsidiary of MorphoSys AG.
This communication contains certain forward-looking statements
MorphoSys group of companies. The forward-looking statements contained
represent the judgment of MorphoSys as of the date of this release and
risks and uncertainties. Should actual conditions differ from the
assumptions, actual results and actions may differ from those
MorphoSys does not intend to update any of these forward-looking
far as the wording of the relevant press release is concerned.
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Source: MorphoSys AG via Thomson Reuters ONE