SOURCE: Eli Lilly and Company

April 19, 2007 14:49 ET

New Survey Shows Most Physicians Believe Diabetes Patients Are Not Receiving Appropriate Care for Diabetic Nerve Pain

New Tools Now Available to Help Improve Diagnostic Communications

INDIANAPOLIS, IN -- (MARKET WIRE) -- April 19, 2007 -- Results from a new survey of more than 600 physicians(i) who treat diabetic peripheral neuropathic pain, or diabetic nerve pain, reveal that nearly all (97 percent) believe that the condition is often misdiagnosed. Overall, findings from the survey, sponsored by the National Pain Foundation (NPF) and Eli Lilly and Company (NYSE: LLY), suggest that more effective communication is needed to ensure proper care for diabetic nerve pain.

Additional survey findings show that:

--  Most physicians surveyed (66 percent) reported that one of the most
    commonly cited reasons leading to misdiagnosis is lack of information from
    their patients
--  Nearly two-thirds of physicians (62 percent) believe that tools or
    guidelines that diabetes patients can use to track diabetic nerve pain
    would be useful in better diagnosing diabetic nerve pain
--  The vast majority of physicians (81 percent) want to find new ways to
    discuss diabetic nerve pain with their patients
    

To achieve these goals, the NPF and Lilly are launching a new educational program called "Talk Beyond Pain: Understanding Diabetic Nerve Pain." This program will provide patients who might be suffering from diabetic nerve pain with the information and vocabulary they need to better communicate with their physicians what they are feeling and experiencing. The materials are available for download at www.TalkBeyondPain.com.

Diabetic nerve pain includes painful symptoms, such as burning, stabbing or shooting pain in the feet and legs or hands and arms. The symptoms can make everyday activities like driving and walking challenging, and can cause feelings of frustration, sadness or fatigue.(ii) (iii)

"Unfortunately, there is no single test that can definitively diagnose diabetic nerve pain. Without a comprehensive understanding of what patients are feeling and experiencing, including the painful physical symptoms and their impact on daily living, it can be easy to misdiagnose diabetic nerve pain and prescribe inappropriate or inadequate treatment," explained Dr. Albert Ray, chairman of the board of the National Pain Foundation and medical director of Pain Medicine Solutions in Miami. "The survey findings suggest that these conversations may not be taking place or not occurring frequently enough, and more guidance for achieving better care can make a huge impact on quality of life."

"Talk Beyond Pain: Understanding Diabetic Nerve Pain" offers education and tools to help patients who believe they may have diabetic nerve pain initiate conversations with their doctors. The following materials are available:

--  "Talk Beyond Pain: Understanding Diabetic Nerve Pain" Educational
    Guide:  This guide details the symptoms of diabetic nerve pain, how they
    may impact everyday life, as well as ways to manage the nerve pain.  It
    also includes worksheets and checklists to help people organize their
    thinking prior to a doctor visit so they can have productive conversations
    and provide healthcare providers with the information necessary for
    appropriate diagnosis.
--  "Talk Beyond Pain: Understanding Diabetic Nerve Pain" Personal Diary:
    This diary helps patients in pain track their symptoms over several weeks,
    as well as their overall well-being in connection with their pain.  There
    is also a section in the diary dedicated to tracking progress to ensure
    people are getting relief from their symptoms with their current treatment
    plan.
    

"We hope that 'Talk Beyond Pain: Understanding Diabetic Nerve Pain' will help to bridge the communication gap between people living with diabetic nerve pain and their physicians, so they can get help and enjoy life again," said Dr. Ray.

The information provided by this program was developed with guidance from the NPF and a group of leading medical experts across different specialties who have come together to form the Partnership for Helping People in Pain. Their goal is to help open the lines of communication between patients and physicians to aid in the diagnosis and treatment process. This partnership began in July 2006 as an initiative between the NPF and Lilly, with discussion surrounding diabetic nerve pain, the most common form of neuropathic pain. Eli Lilly and Company provided both content and financial support to the NPF for this educational campaign.

About Diabetic Nerve Pain

Approximately 5 million people are affected by diabetic nerve pain, however many people at risk are not aware the condition exists.(iv) While the exact cause of diabetic nerve pain is unknown, many factors may be responsible, including high blood sugar, increased weight, smoking, high blood pressure and age older than 40.(v) Though risk increases with age, people with diabetes can develop nerve damage at any time.(vi)

Currently there are no medications that can reverse nerve damage; however, there are medications that can treat the pain associated with diabetic nerve pain. Diabetic nerve pain is not a normal part of aging, and it can affect many facets of a person's life. With the right treatment, diabetic nerve pain can be relieved and kept under control. It's important for people who think they may have diabetic nerve pain to speak with their healthcare provider to ensure proper diagnosis and treatment.

About the Survey

The survey was conducted online within the United States by Harris Interactive® on behalf of the NPF and Lilly between September 18 and 22, 2006, among 605 physicians of whom 252 are primary care physicians, 253 neurologists and 100 endocrinologists who see at least one adult diabetes patient in a typical week. Figures for gender, years in practice and region were weighted where necessary to bring the figures into line with their actual proportions in the population.

With a pure probability sample of 605, it could be said with a 95 percent probability that the overall results have a sampling error of +/-6 percentage points. Sampling error for data from sub-samples would be higher and would vary. However, that does not take other sources of error into account. The online survey is not based on a probability sample and therefore no theoretical sampling error can be calculated.

About the National Pain Foundation

The National Pain Foundation, a non-profit 501(c)(3) organization, was founded in 1998 for the purposes of providing access to peer-reviewed, unbiased information about pain to the public and increasing public awareness of the inadequate treatment of pain. These goals were based on the premise that trustworthy, credible information would empower persons in pain to seek appropriate and effective treatment and that increasing awareness of the public health problem of inadequately treated pain would improve access to appropriate pain services.

The NPF believes that proper treatment of pain conditions at any stage can restore personal functioning and positively change the direction of a person's life. Pain is a disease that needs to be evaluated and managed as comprehensively as any other disease, as it causes untold suffering for millions and is the leading healthcare cost to businesses and society. The NPF believes that successfully increasing pain awareness and empowering people in pain requires numerous perspectives, countless efforts, and the collaboration of many organizations and individuals.

By providing objective, unbiased information to people in pain, to healthcare providers, to insurers and to employers, the NPF addresses the three primary causes of inadequate treatment for pain -- the lack of credible information, the lack of validation of pain as a significant public health problem and the invisibility of pain. By educating people about pain and by explaining both traditional and alternative approaches to treatment, the NPF empowers patients to take a more active role in their treatment.

About Eli Lilly and Company

Lilly, a leading innovation-driven corporation, is developing a growing portfolio of first-in-class and best-in-class pharmaceutical products by applying the latest research from its own worldwide laboratories and from collaborations with eminent scientific organizations. Headquartered in Indianapolis, Ind., Lilly provides answers -- through medicines and information -- for some of the world's most urgent medical needs. Additional information about Lilly is available at www.lilly.com.

(i) 605 physicians, including 252 primary care physicians, 253 neurologists and 100 endocrinologists, who see at least one adult diabetes patients in a typical week participated in this survey. Survey participants were unaware that this survey was sponsored by the National Pain Foundation and Eli Lilly and Company.

(ii) Neuropathy-Specific Quality of Life tool [Note: Per correspondence with Dr. Vileikyte, the tool's developer, the UK version is exactly the same as the US version with 1 exception: UK version says "novacaine-like sensations" and US version says "pins and needles."

(iii) Vileikyte L, Peyrot M, Bundy C et al. The development and validation of a neuropathy- and foot ulcer-specific quality of life instrument. Diabetes Care; 26:9; 2549-2555, 2003.

(iv) "American Diabetes Association Survey Finds Most People with Diabetes Don't Know About Highly Prevalent, Serious Complication." Available at http://www.diabetes.org/for-media/2005-press-releases/diabeticneuropathy.jsp. Accessed on October 5, 2005.

(v) National Diabetes Information Clearing House. "Diabetic Neuropathies: The Nerve Damage of Diabetes." Available at: http://diabetes.niddk.nih.gov/dm/pubs/neuropathies/. Accessed on July 26, 2006.

(vi) National Diabetes Information Clearing House. "Diabetic Neuropathies: The Nerve Damage of Diabetes." Available at: http://diabetes.niddk.nih.gov/dm/pubs/neuropathies/. Accessed on July 26, 2006.

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