SOURCE: Kalorama Information

Kalorama Information

February 25, 2011 10:36 ET

Next-Gen DNA Sequencers Seeing Near-Constant Use in Labs

NEW YORK, NY--(Marketwire - February 25, 2011) -  Sales of next-generation DNA sequencing systems have been growing to the point where most labs performing sequencing now own a next-gen system, reveals a new report from Kalorama Information. According to a survey of labs conducted by the healthcare market research publisher, the results of which are detailed in "Sample Preparation and Library Preparation for DNA Sequencers (Results of The Kalorama Survey of Labs)," the average lab owned three sequencers from a variety of different vendors. The presence and usage of these systems is boosting the market for sample and library preparation products, according to the report.  

"We found most labs performing sequencing had second- and third-generation systems and they were getting a lot of use," said Bruce Carlson, publisher of Kalorama Information. "Approximately 80% of the laboratories had a next-generation sequencer, and they are running most of the time."

Kalorama also identified for what labs were using these next-gen systems. When respondents were asked which applications were most likely to increase between 2010 and 2012, the overwhelming response was resequencing.

The process of DNA sequencing, and thus the market for sequencing products, requires more than just the actual sequencing run itself. It's a multistep process that involves the preparation of samples and target-enrichment systems. The fragmentation and library steps alone can take anywhere from two to six hours, and a poor sample library prep protocol can cause bottlenecks in the lab.

"As more demands are made on labs, the capacity of next-gen sequencers will need to be matched by improvements in sample- and library-prep systems," said Carlson. "Running more samples means it takes more time to do sample and library preparation and these steps are seen as key areas of the process needing improvement in terms of user-friendliness and consistency."

Kalorama Information's "Sample Preparation and Library Preparation for DNA Sequencers (Results of The Kalorama Survey of Labs)" focuses on a survey of 120 laboratories which was carried out from July to September of 2010 with the aim of obtaining a demand-side view of some of the key changes taking place with both next-generation and capillary sequencers. Along with questions about the specific sequencers used in the labs, the respondents were asked about the sample preparation and library preparation kits, reagents, and other consumables used for sequencing. For more information, please visit:

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