SOURCE: Oryzon Genomics

Oryzon Genomics

February 21, 2018 08:00 ET

Oryzon to present at upcoming international conferences

MADRID, SPAIN and CAMBRIDGE, MA--(Marketwired - February 21, 2018) -

  • 6th World CNS Summit: Targeting Neurodegeneration, Boston, Massachusetts US
  • 11th Annual European Life Sciences CEO Forum in Zurich, Switzerland
  • 30th Annual ROTH Conference in Dana Point, California US
  • Alzheimer's disease AAT-AD/PD 2018 Focus Meeting in Torino, Italy

Oryzon Genomics (ISIN Code: ES0167733015) (MAD: ORY), a public clinical-stage biopharmaceutical company leveraging epigenetics to develop therapies in diseases with strong unmet medical need, has announced today that Executive Directors of the company will present at several international reputed conferences.

Dr. Tamara Maes, Oryzon's Vice President and CSO, will present the recent progresses of ORY-2001 at the 6th World CNS Summit: Targeting Neurodegeneration that is being held on February 20-22, 2018 at the Westin Copley Place in Boston, MA. Within the morning session of Conference Day One, "Novel Approaches to Target & Phenotypic Based Discovery," Dr. Maes will present her talk entitled "Modulation of Histone Modifying Enzymes for Treatment of Neurodegenerative Disease" on February 21 at 11:40 am ET. See more info of the event at

Dr. Carlos Buesa and Dr. Roger Bullock, Oryzon's CEO and CMO, respectively, will present the recent progresses of ORY-2001 at the 11th Annual European Life Sciences CEO Forum & Exhibition, which will take place on February 26-27, 2018 at the Hilton Zurich Airport Hotel, Switzerland. In this Conference Dr. Buesa will also be a speaker on the Neuroscience I - Business Development and Licensing Expert's Panel chaired by Jennifer Laird, Senior Director, Search & Evaluation, Eli Lilly & Co. See more info of the event at

Dr. Carlos Buesa and Dr. Tamara Maes will present the recent progresses of the company at the 30th Annual ROTH Conference, to be held on March 11-14, 2018 at The Ritz-Carlton, Laguna Niguel in Dana Point, California. See more info of the event at

In addition, Dr. Roger Bullock will present the recent progresses of ORY-2001 at the Alzheimer's disease conference and Parkinson's disease conference AAT-AD/PD 2018 Focus Meeting to be held on March 15-18, 2018 in the Centro Congressi Lingotto in Torino, Italy. Dr. Bullock will deliver an oral presentation entitled "CAN THE EPIGENETIC DRUG ORY-2001 BE CONSIDERED DISEASE MODIFYING IN ALZHEIMER'S DISEASE?" on March 15 at the SYMPOSIUM 7 - EMERGING TARGETS AND THERAPIES FOR AD AND PD to be held between 16:40 and 18:20. See more info of the event at

The company has recently reported in several scientific conferences that ORY-2001 exerts a holistic action in the different alterations seen in patients with AD and other neurodegenerative disorders. Different experiments suggest that ORY-2001 acts as a disease modifying drug. In AD patients and other neurodegenerative disorders, cognitive deterioration is often accompanied by episodes of agitation, aggression, psychosis, apathy and depression. In preclinical studies, ORY-2001 not only restores memory but reduces the exacerbated aggressiveness of SAMP8 mice to normal levels and also reduces social avoidance in rat models maintained in isolation. The drug has been tested in 6 month rat and 9 month dog GLP toxicology studies to enable long term Phase II studies. The safety and tolerability of ORY-2001 has been studied in a Phase I clinical trial with 106 young and elderly healthy volunteers, confirmed LSD1 target engagement and ORY-2001 brain penetration, and allowed to establish the doses for the Phase II dose finding studies in patients. The company recently started a Phase IIA with ORY-2001 in patients with multiple sclerosis and plans to request soon the corresponding authorizations for a Phase IIA clinical trial in patients with Alzheimer's disease.

ORY-2001 is an orally administered, brain penetrant drug that selectively inhibits LSD1 and MAOB. The molecule acts on several levels, reduces cognitive impairment, memory loss and neuroinflammation, and at the same time exerts neuroprotective effects. In several preclinical models of MS, ORY-2001 exhibits strong and durable efficacy. LSD1 is an epigenetic modulator, which regulates histone methylation and modulates gene expression patterns. Epigenetic approaches to modify the progression of various neurodegenerative diseases, which focus on the production of changes in gene expression patterns in brain cells, have generated interest in the pharmaceutical industry.

About Oryzon
Founded in 2000 in Barcelona, Spain, Oryzon (ISIN Code: ES0167733015) is a clinical stage biopharmaceutical company considered as the European champion in Epigenetics. The company has one of the strongest portfolios in the field. Oryzon's LSD1 program has resulted in + 20 patent families and has rendered two compounds in clinical trials. In addition, Oryzon has ongoing programs for developing inhibitors against other epigenetic targets. The company has a strong technological platform for biomarker identification and performs biomarker and target validation for a variety of malignant and neurodegenerative diseases. Oryzon's strategy is to develop first in class compounds against novel epigenetic targets through Phase II clinical trials, at which point it is decided on a case-by-case basis to either keep the development in-house or to partner or outlicense the compound for late stage development and commercialization. The company has offices in Spain and USA. For more information, visit

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