NEW YORK, NY--(Marketwired - Apr 17, 2014) - A new study shows men with metabolic syndrome-associated conditions are at increased risk of developing intermediate and aggressive prostate cancer. Canadian researchers found a 54 percent increase in prostate cancer diagnosis in men with three or more metabolic syndrome components.
David Samadi, MD, Chief of Robotic Surgery at Lenox Hill Hospital, also studies the impact of metabolic syndrome and obesity on the diagnosis and treatment of prostate cancer. In 2013, he published the results of a nine-year review of more than 2,600 of his own robot-assisted laparoscopic prostatectomy procedures. Men with metabolic syndrome were found to have larger prostates, higher tumor volume, higher pathologic Gleason scores, and increased surgical complexity.
While obesity is associated with a large number of health risks, researchers in the Canadian study noted that weight was not the driving prostate cancer risk factor. Prostate cancer diagnosis was slightly higher among obese men; however, true elevated risk was seen in men with three or more health conditions associated with metabolic syndrome. These men had 56 percent increased odds of developing intermediate- or high-risk prostate cancer. No single metabolic syndrome component was linked to increased risk, http://www.ncbi.nlm.nih.gov/pubmed/24568896
Metabolic syndrome is defined as a group of conditions that often begin with abdominal obesity. Other associated disease factors include diabetes, hypertension, low HDL cholesterol, and hypertriglyceridemia.
"Prevention strategies are critical for men with metabolic syndrome," said Dr. Samadi. "Weight loss and control of cardiovascular conditions is the best place to start. From there, we design tailored screening regimens. The good news is that we can treat prostate cancer in men with metabolic syndrome with robotic surgery."
Dr. Samadi's study demonstrated comparable surgical outcomes between patients with metabolic syndrome and non-obese patients.http://www.ncbi.nlm.nih.gov/pubmed/?term=samadi+metabolic+syndrome