SOURCE: Protherics PLC

June 13, 2008 12:54 ET

Protherics PLC announce Director/PDMR Shareholding

CHESHIRE, UK--(Marketwire - June 13, 2008) -

Protherics PLC

Notification of Director's Interests

London, UK; Brentwood, TN, US: 13 June 2008 - Protherics PLC
("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, announces the vesting, on
12 June 2008, of a Performance Share Award ("Award") to Saul Komisar,
Director of Protherics PLC and President of Protherics Inc. under the
terms of the Company's Deferred Bonus Plan. The Award was made on 12
June 2006 and vests two years from its Date of Grant. 

Pursuant to the vesting of the Award, the Company has
today issued 27,594 Ordinary Shares to Saul Komisar at a nominal value
of 2p per share. 

Following the above transaction, Saul Komisar holds 27,594 Ordinary
Shares (0.008% of the total issued ordinary share capital of the
Company of 340,366,655 Ordinary Shares.The above disclosure is made in accordance with Rule 3.1.4R of
the Disclosure and Transparency Rules.

/ Ends /

For further information please contact:


Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510  

Julie Vickers, Company Secretary            +44 (0)1928 518010

Financial Dynamics - press enquiries

London: Ben Atwell, Lara Mott               +44 (0) 20 7831 3113 

New York: John Capodanno, Jonathan Birt     +1 212 850 5600

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