SOURCE: Protherics PLC

March 19, 2007 14:10 ET

Protherics PLC announce: Holding(s) in Company

Cheshire, UK -- (MARKET WIRE) -- March 19, 2007 --

                                 Protherics PLC


                   Notification of Major Interests in Shares





London, UK; Brentwood, TN, US: 19 March 2007 - Protherics PLC ("Protherics" or
the "Company"), the international biopharmaceutical company focused on critical
care and cancer, announces that, on 16 March 2007, a notification of interest in
the ordinary share capital of the Company was received from AXA Investment
Managers Limited on behalf of AXA S.A. in accordance with the Transparency
Obligations Directive.  Details of the interest notified are as follows:




1. Reason for the notification (please tick the appropriate box or boxes)




An acquisition or disposal of voting rights
An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached



An event changing the breakdown of voting rights


Other (please specify): CONFIRMATION OF CURRENT POSITION USING STANDARD FORM AS      x
REQUIRED BY EUTD REGULATIONS

2. Full name of person(s) subject to the         AXA S.A., 25 Avenue Matignon, 
notification obligation:                         75008 Paris and its group of 
                                                  companies.
3. Full name of shareholder(s) (if different
from 2.):

4. Date of the transaction (and date on which          2 March 2007
the threshold is crossed or reached if
different):
5. Date on which issuer notified:                      16 March 2007
6. Threshold(s) that is/are crossed or reached:


7. Notified details:




A: Voting rights attached to shares
Class/type of     Situation previous to    Resulting situation after the triggering transaction
shares            the Triggering
                  transaction
if possible using Number of   Number of    Number of     Number of voting rights     % of voting rights
the ISIN CODE     Shares      Voting       shares
                              Rights       Direct        Direct        Indirect      Direct    Indirect


GB0007029209                               318,221       318,221       33,039,187    0.09%     9.74%



B: Financial Instruments
Resulting situation after the triggering transaction
Type of financial    Expiration date Exercise/ Conversion      Number of voting rights    % of voting rights
instrument                           Period/ Date              that may be acquired if
                                                               the instrument is
                                                               exercised/ converted.


Total (A+B)
Number of voting rights                           % of voting rights


   33,357,408                                               9.84%


8. Chain of controlled undertakings through which the voting rights and/or the financial instruments are
effectively held, if applicable :



   Name of Company/Fund                    Number of Shares      % of issued share capital


AXA UK Investment Co ICVC                   1,113,331                0.32831
UK Smaller Companies Fund
                   Indirect

Sun Life Pensions Management Ltd               11,250                0.00332
                    Direct

Sun Life Unit Assurance Ltd                    53,913                0.01590
FTSE All Share Tracker
                    Direct

Sun Life Pensions Management                 253,058                 0.07462
FTSE All Share Tracker
                    Direct

AXA Framlington                           13,434,482                 3.96170
UK Select Ops
                   Indirect

AXA Framlington                           13,753,131                 4.05567
Equity Income
                   Indirect
AXA Framlington                            1,329,998                 0.39220
Health
                   Indirect
AXA Framlington                              900,000                 0.26540
Managed Balanced
                   Indirect
AXA Framlington                              592,599                 0.17475
Biotech
                   Indirect
AXA Framlington                              394,259                 0.11626
BAE Systems Pensions Fund CIF Trustees
                   Indirect

AXA Framlington                              176,049                 0.05192
BAE Systems 2000 Pensions Fund
                   Indirect

Framlington onshore private clients        1,289,088                 0.38014
                   Indirect

Framlington onshor private clients            56,250                 0.01659
                   Indirect


               Total Direct                  318,221                 0.09384

             Total Indirect               33,039,187                 9.74295


                      TOTAL               33,357,408                 9.83679

Proxy Voting:

9. Name of the proxy holder:

10. Number of voting rights proxy holder will cease to hold:

11. Date on which proxy holder will cease to hold voting
rights:



12. Additional information:


                                   |  Ends  |


For further information please contact:


Protherics
Nick Staples, Director of Corporate Affairs           +44 (0) 7919  480510
Julie Vickers, Company Secretary                      +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Anna Keeble                       +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt               +1 212 850 5600



Or visit  www.protherics.com


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