SOURCE: Protherics PLC

April 11, 2006 12:49 ET

Protherics PLC announces Blocklisting Interim Review - 1

Cheshire, UK -- (MARKET WIRE) -- April 11, 2006 --

                        BLOCK LISTING SIX MONTHLY RETURN

Information provided on this form must be typed or printed electronically.

To: The FSA

Date: 11 April 2006

Name of applicant:  Protherics PLC

Name of scheme:     Protherics PLC Approved Executive Share Option Scheme

Period of return:   From:     8 October 2005     To:     8 April 2006

Balance under scheme from previous return:                 383,587

The amount by which the block scheme has been increased,  
if the scheme has been increased since the date of the
last return:                                               Nil

Number of securities issued/allotted under scheme during   
period:                                                    21,967

Balance under scheme not yet issued/allotted at end of     
period                                                     361,620

Number and class of securities originally listed and the  
date of admission                                          387,712

Total number of securities in issue at the end of the     
period                                                     259,287,068

Name of contact:                          Julie Vickers

Address of contact:                       The Heath Business and Technical Park
                                          Cheshire  CW7 4QX

Telephone number of contact:              +44 (0) 1928 518000

SIGNED BY   ______________________________________________

            Company Secretary
            for and on behalf of
            Protherics PLC

If you knowingly or recklessly give false or misleading information you may be liable to prosecution.

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