SOURCE: Protherics PLC

October 10, 2006 12:59 ET

Protherics PLC announces Blocklisting Interim Review - 1

Cheshire, UK -- (MARKET WIRE) -- October 10, 2006 --

                      BLOCKLISTING SIX MONTHLY RETURN

INFORMATION PROVIDED ON THIS FORM MUST BE TYPED OR PRINTED ELECTRONICALLY.


To:  The FSA

Date:  10 October 2006


1. Name of applicant:            Protherics PLC



2. Name of scheme                Protherics PLC Unapproved Share Option
                                 Scheme


3. Period of return:             From   8 April 2006        
                                 To    8 October 2006


4. Balance under scheme from 
   previous return:              3,397,817



5. The amount by which the block 
   scheme has been increased, if 
   the scheme has  been increased 
   since the date of the last 
   return:                        Nil



6. Number of securities issued/
   allotted under scheme during 
   period:                        115,000



7. Balance under scheme not yet 
   issued / allotted at end of 
   period                         3,282,817



8. Number and class of securities 
   originally listed and the 
   date of admission              4,559,122 Ordinary Shares 
                                  (date of admission:
                                  (8 April 2005)


9. Total number of securities in 
   issue at the end of the 
   period                         261,147,749


Name of contact                  Julie Vickers


Address of contact               The Heath Business and Technical Park
                                 Runcorn
                                 Cheshire WA7 4QX

Telephone number of contact      +44(0) 1928 518010


SIGNED BY __________________________________________
          Company Secretary
          for and on behalf of
          Protherics PLC


If you knowingly or recklessly give false or misleading information you may be liable to prosecution.



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