SOURCE: Protherics PLC

October 10, 2006 13:22 ET

Protherics PLC announces Blocklisting Interim Review - 3

Cheshire, UK -- (MARKET WIRE) -- October 10, 2006 --

                      BLOCKLISTING SIX MONTHLY RETURN

INFORMATION PROVIDED ON THIS FORM MUST BE TYPED OR PRINTED ELECTRONICALLY.


To:  The FSA

Date: 10 October 2006       


1. Name of applicant:           Protherics PLC

2. Name of scheme               Individual Unapproved Option arrangements

3. Period of return:            From    8 April 2006       
                                To    8 October 2006

4. Balance under scheme from    640,000
previous return:

5. The amount by which the      Nil
block scheme has been 
increased, if the scheme has 
been increased since the 
date of the last return:

6. Number of securities         Nil
issued/allotted under scheme 
during period:

7. Balance under scheme not     640,000
yet issued / allotted at end 
of period

8. Number and class of          810,000 Ordinary Shares 
securities originally listed    (date of admission:
and the date of admission       (8 April 2005)

9. Total number of securities   261,147,749
in issue at the end of the 
period


Name of contact                 Julie Vickers

Address of contact              The Heath Business and Technical Park
                                Runcorn
                                Cheshire WA7 4QX

Telephone number of contact     +44 (0) 1928 518010


Signed by      _____________________________________________________
               Company Secretary
               for and on behalf of
               Protherics PLC


If you knowingly or recklessly give false or misleading information you may be liable to prosecution.



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