April 11, 2006 12:58 ET

Protherics Plc announces Blocklisting Interim Review - 4

Cheshire, UK -- (MARKET WIRE) -- April 11, 2006 --

                        BLOCK LISTING SIX MONTHLY RETURN

Information provided on this form must be typed or printed electronically.

To:  The FSA

Date: 11 April 2006


Name of applicant:    Protherics PLC

Name of scheme:       Protherics PLC Unapproved Share Option Scheme

Period of return:     From:     8 October 2005         To:     8 April 2006

Balance under scheme from previous return:                 4,514,122

The amount by which the block scheme has been increased,   Nil
if the scheme has been increased since the date of the
last return:

Number of securities issued/allotted under scheme during   1,116,305
period:

Balance under scheme not yet issued/allotted at end of     3,397,817
period

Number and class of securities originally listed and the   4,559,122
date of admission

Total number of securities in issue at the end of the      259,287,068
period


Name of contact:                           Julie Vickers

Address of contact:                        The Heath Business and Technical Park
                                           Runcorn
                                           Cheshire  CW7 4QX

Telephone number of contact:               +44 (0) 1928 518000


SIGNED BY   ______________________________________________

Company Secretary
for and on behalf of
Protherics PLC


If you knowingly or recklessly give false or misleading information you may be
liable to prosecution.


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