SOURCE: Protherics PLC

December 18, 2006 14:11 ET

Protherics PLC announces Director/PDMR Shareholding - 1

Cheshire, UK -- (MARKET WIRE) -- December 18, 2006 --

                                 Protherics PLC

                       Notification of Directors' Interests

London, UK; Brentwood, TN; 18 December 2006 - Protherics PLC (the "Company"),
the international biopharmaceutical company focused on critical care and cancer,
announces that, on 15 December 2006, options over 2p ordinary shares in the
Company were granted to the following directors under the terms of the
Protherics PLC Long Term Incentive Plan:

Name                               Number of Options

Andrew J Heath                     215,304
Barry M Riley                      119,322
James C Christie                   118,644

The options are exercisable between the third and tenth anniversary of the date
of grant at a price of 2p per share, subject to the achievement of performance

Following the above grant of options, the above directors hold options over the
following number of shares:

Andrew J Heath                     3,621,900
Barry M Riley                      1,456,227
James C Christie                   1,253,698

The current issued ordinary share capital of the Company is 261,489,793 shares.

                                   |  Ends  |

For further information please contact:

Nick Staples, Director of Corporate Affairs               +44 (0) 7919  480510
Julie Vickers, Company Secretary                          +44 (0)1928 518010

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London: Ben Atwell, David Yates                           +44 (0) 20 7831 3113
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