SOURCE: Protherics PLC

January 04, 2007 13:21 ET

Protherics PLC announces Director/PDMR Shareholding

Cheshire, UK -- (MARKET WIRE) -- January 4, 2007 --


                                 PROTHERICS PLC

                    NOTIFICATION OF INTERESTS OF DIRECTORS


London, UK; Brentwood, TN, US; 4 January 2007: Protherics PLC ("Protherics" or
the "Company"), the international biopharmaceutical company focused on critical
care and cancer, announces that following completion of the Cash Placing, the
Placing and Open Offer, the Glenveigh Licence and the MacroMed Acquisition and
as a result of the Directors taking up all of their entitlements under the
Placing and Open Offer at a price of 65 pence per share, the following
directors' holdings in Ordinary Shares have changed as set out below:

                             Number of Ordinary Shares   Number of Ordinary Shares     Percentage of issued
                              taken up under the Open     following the Open Offer         share capital
                                       Offer
S M Wallis                            62,965                      566,689                      0.17
A J Heath                             43,312                      389,810                      0.11
B M Riley                              3,752                       33,771                      0.01
J C Christie                           3,542                       31,885                      0.01
J R Brown                              2,500                       22,500                      0.01

Protherics current issued Ordinary Share capital is 338,976,174

Terms used in this announcement shall have the same meaning as those used in the
Company's prospectus dated 7 December 2006.


ENDS


For further information contact:

Protherics PLC

Barry Riley, CFO                                            +44 (0) 1928 518 000
Julie Vickers, Company Secretary                            +44 (0) 1928 518 010




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