SOURCE: Protherics PLC

June 12, 2007 13:37 ET

Protherics PLC announces Director/PDMR Shareholding

Cheshire, UK--(Marketwire - June 12, 2007) -

                                 Protherics PLC

                      Notification of Directors' Interests

London, UK; Brentwood, TN, US; 12 June 2007 - Protherics PLC ("Protherics" or
the "Company"), the international biopharmaceutical company focused on critical
care and cancer, today announces the award, on 11 June 2007, of a conditional
right to receive 151,396 ordinary shares in Protherics ("Ordinary Shares") at a
price of 2 pence each under the terms of the Protherics PLC 2005 Long Term
Incentive Plan (the "LTIP"), to Saul Komisar, President of the Company's US

In addition to the above award, on 11 June 2007, Saul Komisar received a
performance bonus in the form of a conditional right to acquire 50,177 Ordinary
Shares at a price of 2 pence each under the terms of the Protherics PLC 2005
Deferred Bonus Plan.

Following the above awards, Saul Komisar holds options and conditional awards
over a total of 1,113,101 Ordinary Shares.

Protherics PLC also announces the grant, on 11 June 2007, of the following
options over Ordinary Shares in the Company under the terms of the LTIP at an
exercise price of 2 pence per share:

Name                       Position                                  Number of

Andrew Heath               Chief Executive Officer                     297,661
Barrington Riley           Finance Director                            161,702
James Christie             Operations Director                         161,702

Following the above grant of options, the above Directors hold options over the
following number of Ordinary Shares:

Andrew Heath                                             3,919,561
Barrington Riley                                         1,576,844
James Christie                                           1,388,010

                                   |  Ends  |

For further information please contact:

Nick Staples, Director of Corporate Affairs                +44 (0) 7919  480510
Julie Vickers, Company Secretary                           +44 (0)1928 518010

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London: Ben Atwell, Anna Keeble                            +44 (0) 20 7831 3113
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