SOURCE: Protherics PLC

June 13, 2008 13:12 ET

Protherics PLC announces Holding(s) in Company - 1

Cheshire, UK--(Marketwire - June 13, 2008) -

Protherics PLC

Notification of Major Interests in Shares

London, UK; Brentwood, TN, US: 13 June 2008 - Protherics PLC
("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, announces that today, in
accordance with the Transparency Obligations
Directive, a notification of interest in the ordinary share capital of
the Company was received from Invesco Perpetual on behalf of Perpetual
Income and Growth Investment Trust. Details of
the interest notified are as follows:

1.  Reason for the notification (please tick the appropriate box or

An disposal of voting rights                                        Yes

An acquisition or disposal of financial instruments which may
result in the acquisition of shares already issued to which voting
rights are attached

An event changing the breakdown of voting rights

Other (please specify):

2. Full name of person(s) subject to the           Perpetual Income and
notification obligation:                           Growth Investment

3. Full name of shareholder(s) (if different from 2.):

4. Date of the transaction (and date on which the  12 June 2008
threshold is crossed or reached if different):

5. Date on which issuer notified:                  13 June 2008

6. Threshold(s) that is/are crossed or reached:    crossed 4% threshold
                                                   into 3%

7. Notified details:

A: Voting rights attached to shares

Class/type of  Situation previous Resulting situation after the triggering
shares         to the Triggering  transaction
if possible
using the ISIN Number of  Number of  Number of Number of voting % of voting
CODE           Shares     Voting     shares    rights           rights
                                                Direct Indirect   Direct
               14,348,079 14,348,079 13,568,085        13,568,085  3.98%
Ordinary 2P

B: Financial Instruments

Resulting situation after the triggering transaction 

Type of     Expiration Exercise/   Number of voting rights that  % of
financial   date       Conversion  may be acquired if the        voting
instrument             Period/     instrument is exercised/      rights
                       Date        converted. 

Total (A+B)

Number of voting rights % of voting rights

13,568,085              3.98%

8. Chain of controlled undertakings through which the voting rights and
/or the financial instruments are effectively held, if applicable :

Name of Company/Fund       Number of    % of issued                   
                           Shares       share capital

Citibank                  13,568,085        3.98% 

Proxy Voting:

9.   Name of the proxy holder:

10. Number of voting rights proxy holder will cease to hold:

11. Date on which proxy holder will cease to hold voting rights:

12. Additional information:

                               / Ends /

For further information please contact:


Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510  

Julie Vickers, Company Secretary            +44 (0)1928 518010

Financial Dynamics - press enquiries

London: Ben Atwell, Lara Mott               +44 (0) 20 7831 3113 

New York: John Capodanno, Jonathan Birt     +1 212 850 5600

Or visit

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