Protherics PLC Notification of Major Interests in Shares London, UK; Brentwood, TN, US: 13 June 2008 - Protherics PLC ("Protherics" or the "Company"), the international biopharmaceutical company focused on critical care and cancer, announces that today, in accordance with the Transparency Obligations Directive, a notification of interest in the ordinary share capital of the Company was received from Invesco Perpetual on behalf of Perpetual Income and Growth Investment Trust. Details of the interest notified are as follows: 1. Reason for the notification (please tick the appropriate box or boxes) An disposal of voting rights Yes An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached An event changing the breakdown of voting rights Other (please specify): 2. Full name of person(s) subject to the Perpetual Income and notification obligation: Growth Investment Trust 3. Full name of shareholder(s) (if different from 2.): 4. Date of the transaction (and date on which the 12 June 2008 threshold is crossed or reached if different): 5. Date on which issuer notified: 13 June 2008 6. Threshold(s) that is/are crossed or reached: crossed 4% threshold into 3% 7. Notified details: A: Voting rights attached to shares Class/type of Situation previous Resulting situation after the triggering shares to the Triggering transaction transaction if possible using the ISIN Number of Number of Number of Number of voting % of voting CODE Shares Voting shares rights rights Rights Direct Indirect Direct Indirect 14,348,079 14,348,079 13,568,085 13,568,085 3.98% Ordinary 2P Shares (GB0007029209) B: Financial Instruments Resulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting rights that % of financial date Conversion may be acquired if the voting instrument Period/ instrument is exercised/ rights Date converted. Total (A+B) Number of voting rights % of voting rights 13,568,085 3.98% 8. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable : Name of Company/Fund Number of % of issued Shares share capital Citibank 13,568,085 3.98% Proxy Voting: 9. Name of the proxy holder: 10. Number of voting rights proxy holder will cease to hold: 11. Date on which proxy holder will cease to hold voting rights: 12. Additional information: / Ends / For further information please contact: Protherics Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510 Julie Vickers, Company Secretary +44 (0)1928 518010 Financial Dynamics - press enquiries London: Ben Atwell, Lara Mott +44 (0) 20 7831 3113 New York: John Capodanno, Jonathan Birt +1 212 850 5600 Or visit www.protherics.com This information is provided by RNS The company news service from the London Stock Exchange END
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