SOURCE: Protherics PLC

April 19, 2006 12:49 ET

Protherics Plc announces Holding(s) in Company

Cheshire, UK -- (MARKET WIRE) -- April 19, 2006 --

                                 PROTHERICS PLC

                    NOTIFICATION OF MAJOR INTERESTS IN SHARES

19 April 2006: Protherics PLC, the biopharmaceutical company focused on critical care and oncology (the "Company"), received notification on 18 April 2006 from Legal & General Investment Management Limited that Legal & General Group PLC and/or its subsidiaries ("Legal & General") has a notifiable interest in 7,964,796 ordinary shares, representing 3.06% of the issued share capital of the Company.

The Company's current issued share capital is 260,097,092 ordinary shares.

ENDS

For further information contact:

 Protherics PLC                             +44 (0) 20 7246 9950
 Julie Vickers, Company Secretary           +44 (0) 1928 518010
 Nick Staples, Corporate Affairs            +44 (0) 7919 480510  (mobile)

 Financial Dynamics                         +44 (0) 20 7831 3113
 Ben Atwell/David Yates



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