SOURCE: Protherics PLC

June 22, 2006 13:19 ET

Protherics PLC announces Holding(s) in Company

Cheshire, UK -- (MARKET WIRE) -- June 22, 2006 --

                                 PROTHERICS PLC



                  NOTIFICATION OF MAJOR INTERESTS IN SHARES

22 June 2006: Protherics PLC, the biopharmaceutical company focused on critical care and oncology (the "Company"), received notification from Aviva plc on 21 June 2006 that, as at 20 June 2006, Aviva plc and its subsidiaries held an interest in 29,061,225 ordinary shares, representing 11.16% of the issued share capital of the Company.

The Shares are represented by a beneficial interest in 12,144,826 ordinary shares (4.66%) and a non-beneficial interest in 16,916,399 ordinary shares (6.50%).

This notification follows the purchase of 540,367 ordinary shares representing 0.21% of the issued share capital of the Company.

The issued share capital of the Company is 260,295,464 ordinary shares.

ENDS

For further information contact:


Protherics PLC                           +44 (0) 20 7246 9950
Julie Vickers, Company Secretary         +44 (0) 1928 518010
Nick Staples, Corporate Affairs          +44 (0) 7919 480510 (mobile)


Financial Dynamics                       +44 (0) 20 7831 3113
Ben Atwell/David Yates






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