SOURCE: Protherics PLC

June 23, 2006 07:22 ET

Protherics Plc announces Holding(s) in Company

Cheshire, UK -- (MARKET WIRE) -- June 23, 2006 --

                                 PROTHERICS PLC

                    NOTIFICATION OF MAJOR INTERESTS IN SHARES

23 June 2006: Protherics PLC, the biopharmaceutical company focused on critical care and oncology (the "Company"), received notification from Fidelity International Limited on 22 June 2006 that, as at 21 June 2006, Fidelity International Limited and its direct and indirect subsidiaries, being non-beneficial holders, held an interest in 10,315,273 ordinary shares, representing 3.96% of the issued share capital of the Company.

This notification follows a reduction of 1,376,334 ordinary shares in their holding, representing 0.53% of the issued share capital of the Company.

The current issued share capital of the Company is 260,295,464 ordinary shares.

ENDS

For further information contact:

Protherics PLC                             +44 (0) 20 7246 9950
Julie Vickers, Company Secretary           +44 (0) 1928 518010
Nick Staples, Corporate Affairs            +44 (0) 7919 480510 (mobile)

Financial Dynamics                         +44 (0) 20 7831 3113
Ben Atwell/David Yates



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