SOURCE: Protherics PLC

November 30, 2006 11:47 ET

Protherics PLC announces Holding(s) in Company

Cheshire, UK -- (MARKET WIRE) -- November 30, 2006 --

                          Protherics PLC

                    Notification of Major Interest in Shares

London, UK; Brentwood, TN; 30 November 2006 - Protherics PLC ("Protherics" or the "Company"), the international biopharmaceutical company focused on critical care and cancer, announces that, on 29 November 2006, it received notification from Aviva plc that, as at 27 November 2006, Aviva plc and its subsidiaries held an interest in 31,441,191 ordinary shares, representing 12.02% of the issued share capital of the Company

The Shares are represented by a beneficial interest in 17,502,185 ordinary shares (6.69%) and a non-beneficial interest in 13,939,006 ordinary shares (5.33%).

This notification follows the purchase of 105,500 ordinary shares on 27 November 2006 representing 0.04% of the issued share capital of the Company.

The issued share capital of the Company is 261,487,953 ordinary shares.

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For further information please contact:

 Protherics
 Nick Staples, Director of Corporate Affairs      +44 (0) 7919  480510
 Julie Vickers, Company Secretary                 +44 (0)1928 518010

 Financial Dynamics - press enquiries
 London: Ben Atwell, David Yates                  +44 (0) 20 7831 3113
 New York: John Capodanno, Jonathan Birt          +1 212 850 5600

Or visit  www.protherics.com



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